Modulating Mitochondrial Metabolism as a Protective Strategy in Cardiac Ischemic Injury
Thursday, May 20th, 2010
9:30 am Seattle | 12:30 pm New York | 18:30 Stockholm
Paul Brookes, Ph.D.
Associate Professor
University of Rochester
Medical Center
Webinar Abstract:
Mitochondria contribute the bulk of ATP synthesis in the heart, and the dysfunction of mitochondrial metabolism in post-ischemic tissue has been studied for several decades. More recently, it has become appreciated that mitochondria play a critical role in endogenous signaling pathways such as ischemic preconditioning, which can protect the heart against ischemia-reperfusion (IR) injury. It has also recently been found that many reversible inhibitors of mitochondrial respiration are cardioprotective in animal models of IR injury. This talk will investigate some of the mechanisms by which reversible mitochondrial inhibition is protective, and discuss some of the strategies available for using the XF instrument in studying ischemia/hypoxia.
You Will Learn:
- Understand the "gradual wake-up" hypothesis of cardiac ischemic protection, and the roles that mitochondrial metabolism plays in both the ischemic and reperfused heart.
- Understand the type of approach available to study ischemia/hypoxia in a plate reader format such as the XF-24.
- Understand some of the issues associated with drug development and screening within the specific field of cardiac ischemia (myocardial infarction.)
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