Molecular scaffolds KSR1/2: Implications for obesity and cancer
Robert Lewis, Ph.D.
Professor
Eppley Institute for Research in Cancer & Allied Diseases
University of Nebraska Medical Center
Omaha, NE
Webinar Abstract:
Recent studies illustrate how distinct growth factor-regulated and nutrient-regulated signaling pathways can converge upon the same critical effectors to alter cell fate. Molecular scaffolds, which coordinate the interaction of signaling molecules to promote efficient signal transduction, might also serve as organizing nodes to integrate signals from growth factors and nutrients affecting cell homeostasis. Kinase Suppressor of Ras 1 and 2 (KSR1 and KSR2) function as molecular scaffolds to potently regulate the MAP kinases ERK1/2 and direct multiple cell fates.
We have found that KSR2 interacts with and modulates fatty acid oxidation in vitro. Disruption of KSR2 in vivo causes obesity and insulin resistance.
Join us for this 45-minute webinar to learn how we are employing XF technology to understand how molecular scaffolds affect energy balance in cells.
You Will Learn:
- The role of KSR proteins in regulating AMPK signaling.
- How KSR2 affects energy expenditure in vivo.
- How KSR1 may alter oncogenic potential by regulating the glycolytic and oxidative capacity of tumor cells
Assay:
Mitochondrial Function: FCCP
Substrate Utilization: Palmitate
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