The Bioenergetics of Obesity: New Approaches to Characterize Genes Affecting Energy Balance in Mouse Models
Guest Speaker:
Karen Reue, PhD
Professor, Department of Human Genetics
David Geffen School of Medicine at UCLA
Karen Reue, PhD
Professor, Department of Human Genetics
David Geffen School of Medicine at UCLA
Webinar Abstract:
Obesity is strongly associated with the prevalence of metabolic diseases such as type 2 diabetes and cardiovascular disease. At its root, obesity is a consequence of energy intake that exceeds energy expenditure. The identification of genes and mechanisms that influence energy balance has been facilitated by studies in genetically modified mouse models.
During this 45-minute webinar I will discuss specific lipid metabolism genes that have roles in energy expenditure in muscle and brown adipose tissue, and approaches to characterize their cellular functions using primary cells from mouse models.
You Will Learn:
- Important roles for lipid metabolism genes in energy balance in vivo
- Measuring bioenergetics in primary cells isolated from genetically modified mouse models
- Screening for novel energy metabolism genes
Assay:
Energy Expenditure: Glycolytic Flux
Mitochondrial Function: BOFA
Substrate Utilization: Palmitate, Etomoxin
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