Cybrid Modeling of Sporadic Neurodegenerative Disorders
Russell H. Swerdlow, MDUniversity of Kansas School of Medicine
Webinar Abstract:
Several human diseases are characterized by mitochondrial dysfunction and only rare Mendelian inheritance. The most appropriate way to model mitochondrial dysfunction in sporadic disease is a controversial issue that awaits definitive resolution. My collaborators and I have used the cytoplasmic hybrid, or cybrid, technique to model mitochondrial function in sporadic neurodegenerative diseases.
Join us for this 45-minute webinar to review the results of these studies and other related investigation.
You Will Learn:
- To understand the conceptual basis of the cybrid technique
- To review methodologic issues relating to making and assaying cybrid cell lines
- To discuss results and interpretations of studies in which the cybrid approach was used to model mitochondrial function in sporadic neurodegenerative diseases
Assay:
Mitochondrial Function: BOFA
Log In to View on-DemandBiography
Dr. Swerdlow is a professor in the departments of Neurology and Molecular & Integrative Physiology at the University of Kansas School of Medicine. Dr. Swerdlow's research focuses on the role of mitochondrial genes and physiology in brain aging and neurodegenerative diseases.