Protective Bioenergetic Responses of Cardiomyocytes to Hypoxic Stress
Guest Speaker:
Gary L. Wright, Ph.D
Assistant Professor Department of Pharmaceutical Sciences Medical University of South Carolina
Webinar Abstract:
The prolyl hydroxylase (PHD) oxygen-sensor has emerged as the central signaling pathway that mediates the cellular response to hypoxia. Elucidation of PHD-directed changes in cellular metabolism is crucial for the understanding the etiology of ischemic pathologies. Learn about the fundamental changes in heart cell metabolism and physiology that comprise the protective metabolic program employed against hypoxic stress.
Also discussed:
- The utility of contracting cardiomyocyte cultures in exploring the mechanisms of drugs that impact metabolic function
- The critical importance of adequate ATP turnover and workload when evaluating mitochondrial metabolism
- The mechanism via which cells down regulate ATP turnover independent from ATP synthesis
Assay:
Energy Expenditure: Shift between mitochondrial respiration and glycolysis (DMOG, Hifla)
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