Thyroid Hormone Deiodination is a Key Switch for Energy Expenditure
Guest Speaker:
Antonio Bianco, MD, PhD
Chief, Thyroid Section Brigham and Women's Hospital, Associate Professor of Medicine Harvard Medical School
Webinar Abstract:
Thyroid hormone is an iodinated compound known to influence gene expression in virtually every vertebrate tissue. In fact, T3 is one of the most potent thermogenic molecules produced by mammals. Although all cells are exposed to essentially the same circulating concentrations of thyroid hormone, only certain cells express deiodinases, which are enzymes that modulate local thyroid hormone signaling. This 45-minute webinar discusses how specific iodothyronine deiodinases can be manipulated to alter thyroid hormone signaling as a means to better understand energy homeostasis and metabolic control.
Also discussed:
- About the hormonal control of thermogenesis
- How deiodinases regulate thyroid hormone signaling
- Nutritional signals that can influence energy homeostasis and metabolic control
Assay:
Mitochondrial Function: OCR
Log In to View on-DemandOriginally presented March 25, 2008
References and Additional Links
Select References:
Huang SA, Bianco AC. Reawakened interest in type III iodothyronine deiodinase in critical illness and injury Nature Clin Pract Endocrinol Metab 2008;4:148-55
da-Silva WS, Harney JW, Kim BW, Li J, Bianco SD, Crescenzi A, Christoffolete MA, Huang SA, Bianco AC. The small polyphenolic molecule Kaempferol increases thyroid hormone activation and cellular energy expenditure. Diabetes 2007;56:767-776
Sagar GDV, Gereben B, Callebaut I, Mornon J-P, Zeöld A, da Silva WS, Luongo C, Dentice M, Tente SM, Freitas BCG, Harney JW, Zavacki AM, Bianco AC. Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity. Mol Cell Biol 2007;27:4774-83.
Bianco AC, Kim BW-S. Deiodinases: Implications of the local control of thyroid hormone action. J Clin Invest 2006;116:2571-2579.