Bioenergetic Consequences of Mitochondrial Fusion and Fission
Guest Speaker:
Orian Shirihai, M.D., Ph.D.
Assistant Professor of Pharmacology and Experimental Therapeutics
Tufts University School of Medicine-Boston
Webinar Abstract:
Mitochondria in the living cell exist as a dynamic network that is constantly remodeled by fusion and fission events. Recent work has demonstrated that inhibition of fusion and fission affect mitochondrial functions including respiration and apoptosis, and reveal how continuous breakdown and reconnection of the mitochondrial architecture may affect mitochondrial bioenergetics. This 45- minute webinar discusses how bioenergetic efficiency of the mitochondrial population within a cell may be quality controlled.
Also discussed:
- About how individual mitochondria can be tagged and tracked through fusion and fission
- About the bioenergetic consequences of inhibition of mitochondrial fission
- How the axis of fusion, fission and autophagy operate as a quality control mechanism
Assay:
Mitochondrial Function: FCCP
Log In to View on-DemandOriginally presented January 30, 2008
References and Additional Links
Shirihai Research Lab Website:
http://www.tufts.edu/central/research/ResearchNews/Researchers/Shirihai.htm