Publications

2010

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.

Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ, (2010) Nat Immunol. Mar;11(3):265-72. Epub 2010 Feb 7.

Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts.

Moran M, Rivera H, Sanchez-Arago M, Blazquez A, Merinero B, Ugalde C, Arenas J, Cuezva JM, Martin MA; (2010) Biochim Biophys Acta. Feb 11. [Epub ahead of print]

Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration

Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, Salomoni P, Nicotera P.; (2010) Hum Mol Genet. Feb 1. [Epub ahead of print]

Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species.

Dranka BP, Hill BG, Darley-Usmar VM.; (2010) Free Radic Biol Med. Jan 18. [Epub ahead of print]

A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells.

Shaham O, Slate NG, Goldberger O, Xu Q, Ramanathan A, Souza AL, Clish CB, Sims KB, Mootha VK.; (2010) Proc Natl Acad Sci U S A. Jan 8. [Epub ahead of print]

UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.

Yang Y, Valera VA, Padilla-Nash HM, Sourbier C, Vocke CD, Vira MA, Abu-Asab MS, Bratslavsky G, Tsokos M, Merino MJ, Pinto PA, Srinivasan R, Ried T, Neckers L, Linehan WM.; (2010) Cancer Genet Cytogenet. Jan 1;196(1):45-55.

2009

Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77.

Chao LC, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva OR, Ding SY, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL, Tontonoz P.; (2009) Diabetes. Dec;58(12):2788-96.

Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies.

Swerdlow, Russel H, (2009) Pharmaceuticals; 2(3), 150-167.

Regulation of vascular smooth muscle cell bioenergetic function by protein glutathiolation.

Hill BG, Higdon AN, Dranka BP, Darley-Usmar VM.; (2009) Biochim Biophys Acta.; Nov 24. [Epub ahead of print]

KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.

Costanzo-Garvey DL, Pfluger PT, Dougherty MK, Stock JL, Boehm M, Chaika O, Fernandez MR, Fisher K, Kortum RL, Hong EG, Jun JY, Ko HJ, Schreiner A, Volle DJ, Treece T, Swift AL, Winer M, Chen D, Wu M, Leon LR, Shaw AS, McNeish J, Kim JK, Morrison DK, Tschop MH, Lewis RE.; (2009) Cell Metab. Nov;10(5):366-78.

MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU½

Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J., (2009) Cell Metab. Oct;10(4):273-84.

Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha.

Wu N, Yin L, Hanniman EA, Joshi S, Lazar MA., (2009) Genes Dev. Sept 15;23(18):2201-9.

Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal.

Hill BG, Dranka BP, Zou L, Chatham JC, Darley-Usmar V., (2009) Biochem J. Sep 10. [Epub ahead of print

TGR5-mediated bile acid sensing controls glucose homeostasis.

Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J, Schoonjans K., (2009) Cell Metab. Sept;10(3):167-77.

Polo-like kinases mediate cell survival in mitochondrial dysfunction.

Matsumoto T, Wang PY, Ma W, Sung HJ, Matoba S, Hwang PM., (2009) Proc Natl Acad Sci U S A., Aug 25;106(34):14542-6. (XF24 data is in the supplement to this paper.)

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease.

Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD., (2009) Proc Natl Acad Sci U S A. Aug 10. [Epub ahead of print]

Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype.

de Groof AJ, Te Lindert MM, van Dommelen MM, Wu M, Willemse M, Smift AL, Winer M, Oerlemans F, Pluk H, Fransen JA, Wieringa B., (2009) Mol Cancer, Jul 31;8(1):54.

Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion.

Akos A. Gerencser, Andy Neilson, Sung W. Choi, Ursula Edman, Nagendra Yadava, Richard J. Oh, David A. Ferrick, David G. Nicholls and Martin D. Brand (2009) Anal. Chem., Publication Date (Web): June 25, 2009

Mice lacking phosphatidylcholine transfer protein/StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue.

Kang HW, Ribich S, Kim BW, Hagen SJ, Bianco AC, Cohen DE (2009) J Lipid Res. Jun 6. [Epub ahead of print]

C/EBP{alpha} and the corepressors CtBP1/2 regulate repression of select visceral white adipose genes during the induction of the brown phenotype in white adipocytes by PPAR{gamma} agonists.

Vernochet C, Peres SB, Davis KE, McDonald ME, Qiang L, Wang H, Scherer PE, Farmer SR. (2009) Mol Cell Biol. Jun 29. [Epub ahead of print]

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.

Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J. (2009) Nature. 2009 Apr 23;458(7241):1056-60.

Bmi1 regulates mitochondrial function and the DNA damage response pathway.

Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, Xu XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T. (2009) Nature. 459(7245):387-92.

Bioenergetic Analysis of Isolated Cerebrocortical Nerve Terminals on a Microgram Scale: Spare Respiratory Capacity and Stochastic Mitochondrial Failure.

Choi WS, Gerencser AA, Nicholls DG., J. Neurochem. 109 : 1179-1191, 2009

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy.

J. Julie Wu, Celia Quijano, Edmund Chen, Hongjun Liu, Liu Cao, Maria M. Fergusson, Ilsa I. Rovira, Sarah Gutkind, Mathew P. Daniels, Masaaki Komatsu and Toren Finkel, (2009) Aging, April Vol. 1. No 4

Hyaluronan, CD44, and Emmprin Regulate Lactate Efflux and Membrane Localization of Monocarboxylate Transporters in Human Breast Carcinoma Cells.

Slomiany MG, Grass GD, Robertson AD, Yang XY, Maria BL, Beeson C, Toole BP. (2009) Cancer Res. 69(4):1293-1301.

2008

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.

Dykens JA, Jamieson J, Marroquin L, Nadanaciva S, Billis PA, Will Y. (2008) Toxicol Appl Pharmacol: 233(2):203-10.

O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration.

Sridharan V, Guichard J, Li CY, Muise-Helmericks R, Beeson CC, Wright GL. (2008) Am J Physiol Cell Physiol. 295(1):C29-37.

Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.

Simonides WS, Mulcahey MA, Redout EM, Muller A, Zuidwijk MJ, Visser TJ, Wassen FW, Crescenzi A, da-Silva WS, Harney J, Engel FB, Obregon MJ, Larsen PR, Bianco AC, Huang SA. (2008) J Clin Invest. 118(3):975-83.

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation.

Jerome N. Feige, Marie Lagouge, Carles Canto, Axelle Strehle, Sander M. Houten, Jill C. Milne, Philip D. Lambert, Chikage Mataki, Peter J. Elliott, and Johan Auwerx. (2008) Cell Metabolism 8, 347–358.

In vitro assessment of mitochondrial dysfunction and cytotoxicity of Nefazodone, Trazodone and Buspirone.

Dykens JA, Jamieson JD, Marroquin LD, Nadanaciva S, Xu JJ, Dunn MC, Smith AR, and Will Y. (2008) Toxicol Sci. (2):335-45.

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.

Twig G, Elorza A, Molina AJA, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, and Shirihai OS. (2008) EMBO J 27(2):433-46.

Advances in measuring cellular bioenergetics using extracellular flux.

Ferrick DA, Neilson A, and Beeson C. (2008) Drug Discov Today. 13(5-6):268-74.

2007

ERRγ directs and maintains the transition to oxidative metabolism in the postnatal heart.

Alaynick WA, Kondo RP, Xie W, He W, Dufour CR, Downes M, Jonker JW, Giles W, Naviaux RK, Giguere V and Evans RM. (2007) Cell Metab 6:13-24 (XF24 data is in the supplement to this paper).

Peroxisome proliferator activator receptor γ coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.

Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC and Patti ME. (2007) J Biol Chem 282:15439-15450.

The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation

da-Silva WS, Harney JW, Kim BW, Li J, Bianco SD, Crescenzi A, Christoffolete MA, Huang SA and Bianco AC. (2007) Diabetes 56:767-776.

The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition.

Sridharan V, Guichard J, Bailey RM, Kasiganesan H, Beeson C and Wright GL. (2007) Am J Physiol Cell Physiol 292:C719-C728.

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells.

Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S and Ferrick DA. (2007) Am J Physiol Cell Physiol 292:C125-C136.

2006

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.

Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC and Auwerx J. (2006) Nature 439:484-489.