Publications

Alaynick WA, Kondo RP, Xie W, He W, Dufour CR, Downes M, Jonker JW, Giles W, Naviaux RK, Giguere V, and Evans RM,

ERRγ directs and maintains the transition to oxidative metabolism in the postnatal heart. Cell Metab 6:13-24, 2007 (XF24 data is in the supplement to this paper).

Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, Salomoni P, Nicotera P.; (2010) Hum Mol Genet. Feb 1.

Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration. [Epub ahead of print]

Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J,

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 458(7241):1056-60, 2009

Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. (2010) Nat Immunol. Mar;11(3):265-72. Epub 2010 Feb 7.

Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J., MicroRNA-210

Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2, Cell Metab. Oct;10(4):273-84, 2009.

Chao LC, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva OR, Ding SY, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL, Tontonoz P.

Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77;. (2009) Diabetes. Dec;58(12):2788-96.

Choi WS, Gerencser AA, Nicholls DG.

Bioenergetic Analysis of Isolated Cerebrocortical Nerve Terminals on a Microgram Scale: Spare Respiratory Capacity and Stochastic Mitochondrial Failure. Journal of Neurochemistry. 109 : 1179-1191, 2009.

Costanzo-Garvey DL, Pfluger PT, Dougherty MK, Stock JL, Boehm M, Chaika O, Fernandez MR, Fisher K, Kortum RL, Hong EG, Jun JY, Ko HJ, Schreiner A, Volle DJ, Treece T, Swift AL, Winer M, Chen D, Wu M, Leon LR, Shaw AS, McNeish J, Kim JK, Morrison DK, Tschop MH, Lewis RE.; (2009) Cell Metab. Nov;10(5):366-78.

KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity, (2009) Cell Metab. Nov;10(5):366-78.

Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, and Patti ME,

Peroxisome proliferator activator receptor γ coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem 282:15439-15450, 2007.

da-Silva WS, Harney JW, Kim BW, Li J, Bianco SD, Crescenzi A, Christoffolete MA, Huang SA and Bianco AC.

The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes 56:767-776, 2007.

de Groof AJ, Te Lindert MM, van Dommelen MM, Wu M, Willemse M, Smift AL, Winer M, Oerlemans F, Pluk H, Fransen JA, Wieringa B.

Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype., (2009) Mol Cancer, Jul 31;8(1):54.

Dranka BP, Hill BG, Darley-Usmar VM.

Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species. (2010) Free Radic Biol Med. Jan 18. [Epub ahead of print]

Dykens JA, Jamieson J, Marroquin L, Nadanaciva S, Billis PA, Will Y.

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. Toxicol Appl Pharmacol: 233(2):203-10, 2008

Dykens JA, Jamieson JD, Marroquin LD, Nadanaciva S, Xu JJ, Dunn MC, Smith AR, and Will Y.

In vitro assessment of mitochondrial dysfunction and cytotoxicity of Nefazodone, Trazodone and Buspirone. Toxicol Sci. (2):335-45, 2008.

Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, and Auwerx J,

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation. Cell Metabolism 8, 347–358, 2008.

Ferrick DA, Neilson A, and Beeson C.

Advances in measuring cellular bioenergetics using extracellular flux. Drug Discov Today. 13(5-6):268-74, 2008

Gerencser AA, Neilson A, Choi SW, Edman U, Yadava N, Oh RJ, Ferrick DA, Nicholls DG, and Brand MD

Anal. Chem., Publication Date (Web): June 25, 2009, Quantitative Microplate-Based Respirometry with Correction for Oxygen Diffusion

Hill BG, Dranka BP, Zou L, Chatham JC, Darley-Usmar V.

(2009) Biochem J. Sep 10. [Epub ahead of print]. Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal.

Hill BG, Higdon AN, Dranka BP, Darley-Usmar VM.; (2009) Biochim Biophys Acta.; Nov 24. [Epub ahead of print]

Regulation of vascular smooth muscle cell bioenergetic function by protein glutathiolation.

Kang HW, Ribich S, Kim BW, Hagen SJ, Bianco AC, Cohen DE.

Mice lacking phosphatidylcholine transfer protein/StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. J Lipid Res. Jun 6, 2009. [Epub ahead of print]

Liu, J., Cao, L., Chen, J., Song, S., Lee, IH, Quijano, C., Liu, H., Keyvanfar, K., Chen, H., Cao, L.Y., Ahn, B.H., Kumar, N.G., Rovira, I.I., Xu, X.L., van Lohuizen, M., Motoyama, N., Deng, C.X,, Finkel, T.

Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature. 459(7245):387-92, 2009

Matsumoto T, Wang PY, Ma W, Sung HJ, Matoba S, Hwang PM.

Polo-like kinases mediate cell survival in mitochondrial dysfunction., Proc Natl Acad Sci, U S A., Aug 25;106(34):14542-6, 2009. (XF24 data is in the supplement to this paper).

Moran M, Rivera H, Sanchez-Arago M, Blazquez A, Merinero B, Ugalde C, Arenas J, Cuezva JM, Martin MA

Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts. (2010) Biochim Biophys Acta. Feb 11. [Epub ahead of print]

Shaham O, Slate NG, Goldberger O, Xu Q, Ramanathan A, Souza AL, Clish CB, Sims KB, Mootha VK

A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells..; Proc Natl Acad Sci U S A. 2010 Jan 8. [Epub ahead of print]

Simonides WS, Mulcahey MA, Redout EM, Muller A, Zuidwijk MJ, Visser TJ, Wassen FW, Crescenzi A, da-Silva WS, Harney J, Engel FB, Obregon MJ, Larsen PR, Bianco AC, Huang SA.

Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. J Clin Invest. 118(3):975-83, 2008

Slomiany MG, Grass GD, Robertson AD, Yang XY, Maria BL, Beeson C, Toole BP.

Hyaluronan, CD44, and Emmprin Regulate Lactate Efflux and Membrane Localization of Monocarboxylate Transporters in Human Breast Carcinoma Cells. Cancer Res. 69(4):1293-1301, 2009

Sridharan V, Guichard J, Li CY, Muise-Helmericks R, Beeson CC, Wright GL .

O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration. Am J Physiol Cell Physiol. 295(1):C29-37, 2008

Sridharan V, Guichard J, Bailey RM, Kasiganesan H, Beeson C and Wright GL.

The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition. Am J Physiol Cell Physiol 292:C719-C728, 2007.

Swerdlow, Russel H, (2009) Pharmaceuticals; 2(3), 150-167.

Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies.

Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J, and Schoonjans K.

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis. Cell Metabolism 10(3):167-177, 2009

Twig G, Elorza A, Molina AJA, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, and Shirihai OS.

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 27(2):433-46. 2008

Vernochet C, Peres SB, Davis KE, McDonald ME, Qiang L, Wang H, Scherer PE, Farmer SR.

C/EBP{alpha} and the corepressors CtBP1/2 regulate repression of select visceral white adipose genes during the induction of the brown phenotype in white adipocytes by PPAR{gamma} agonists. Mol Cell Biol. Jun 29, 2009. [Epub ahead of print]

Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC and Auwerx J.

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439:484-489, 2006

Wu J. J., Quijano,C., Chen, E., Liu, H., Cao, L., Fergusson, M.M., Rovira, I.I., Gutkind, S., Daniels, M.P., Komatsu, M., and Finkel, T.

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy Aging, April Vol. 1. No 4, 2009

Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S and Ferrick DA.

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 292:C125-C136, 2007.

Wu N, Yin L, Hanniman EA, Joshi S, Lazar MA.

Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha., Genes Dev. Sept 15;23(18):2201-9, 20009.

Xie H, Valera VA, Merino MJ, Amato AM, Signoretti S, Linehan WM, Sukhatme VP, Seth P.

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. Mol Cancer Ther. 2009 Mar; 8(3):626-35, (2009)

Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD.

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease., (2009) Proc Natl Acad Sci U S A. Aug 10. [Epub ahead of print]

Yang Y, Valera VA, Padilla-Nash HM, Sourbier C, Vocke CD, Vira MA, Abu-Asab MS, Bratslavsky G, Tsokos M, Merino MJ, Pinto PA, Srinivasan R, Ried T, Neckers L, Linehan WM.; (2010) Cancer Genet Cytogenet. Jan 1;196(1):45-55.

UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.

Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD.,

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease., (2009) Proc Natl Acad Sci U S A. Aug 10. [Epub ahead of print]