Bioenergetic Profiling in Translational Neuroscience

As the largest single consumer of oxygen in the body, the brain is exquisitely sensitive to changes in bioenergetic loads. Neurons require high bursts of rapid and transient ATP production to restore and maintain membrane polarization and cellular viability following synaptic activation. Not surprisingly, many diseases of the central nervous system, including Alzheimer’s disease, are associated with mitochondrial dysfunction. Learn how elucidation of the mechanisms of agents that positively modify these bioenergetic defects is essential for the development of therapeutics for neurodegeneration.

Also discussed:

• The regulation of neuronal bioenergetics by the ovarian hormones
• How bioenergetics can be used to dissect the mechanistic underpinnings of neuroactive therapeutic agent
• How bioenergetics can be used to understand neuropathological processes

View On-Demand Webinar*

June 25, 2008

Event ID#110767

References and Additional Links

University of Southern California School of Pharmacy Website:

http://www.usc.edu/schools/pharmacy/

Contact Information

Jon Nilsen, Ph.D
Assistant Professor, Dept. of Pharmacology and Pharmaceutical Sciences, University of Southern California
Email: jnilsen@usc.edu

 

Selected Projects/Publications

1. Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. Irwin RW, Yao J, Hamilton RT, Cadenas E, Brinton RD, Nilsen J.

2. Estradiol in vivo regulation of brain mitochondrial proteome. Nilsen J, Irwin RW, Gallaher TK, Brinton RD.

3. Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function. Nilsen J, Chen S, Irwin RW, Iwamoto S, Brinton RD.

Reviews

1. Mitochondria as therapeutic targets of estrogen action in the central nervous system. Nilsen J, Brinton RD.

2. Estradiol and neurodegenerative oxidative stress. Jon Nilsen.

*None of the content on this website should be considered medical or psychological advice. Seahorse Biosciences does not give medical advice or diagnose medical and psychological conditions. Although every effort is made to assure that information on this site is accurate and current, knowledge in the field of cellular bioenergetics is growing rapidly and all data is subject to change without notice. You should consult with your healthcare professional for specific advice relating to your medical questions or conditions. None of the information, statements and/or links contained on the website are intended to replace the attention or medical instructions from a healthcare professional. Only your practitioner can completely and appropriately assess your situation and make conclusive decisions regarding your care.

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