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Thyroid Hormone Deiodination is a Key Switch for Energy Expenditure
Guest Speaker:
Antonio C. Bianco, M.D., Ph.D.
Chief, Thyroid Section Brigham and Women’s Hospital, Associate Professor of Medicine Harvard Medical School
Thyroid hormone is an iodinated compound known to influence gene expression in virtually every vertebrate tissue. In fact, T3 is one of the most potent thermogenic molecules produced by mammals. Although all cells are exposed to essentially the same circulating concentrations of thyroid hormone, only certain cells express deiodinases, which are enzymes that modulate local thyroid hormone signaling. This 45-minute webinar discusses how specific iodothyronine deiodinases can be manipulated to alter thyroid hormone signaling as a means to better understand energy homeostasis and metabolic control.
Also discussed:
- About the hormonal control of thermogenesis
- How deiodinases regulate thyroid hormone signaling
- Nutritional signals that can influence energy homeostasis and metabolic control
View On-Demand Webinar*
References and Additional Links
Select References:
Huang SA, Bianco AC. Reawakened interest in type III iodothyronine deiodinase in critical illness and injury Nature Clin Pract Endocrinol Metab 2008;4:148-55
da-Silva WS, Harney JW, Kim BW, Li J, Bianco SD, Crescenzi A, Christoffolete MA, Huang SA, Bianco AC. The small polyphenolic molecule Kaempferol increases thyroid hormone activation and cellular energy expenditure. Diabetes 2007;56:767-776
Sagar GDV, Gereben B, Callebaut I, Mornon J-P, Zeöld A, da Silva WS, Luongo C, Dentice M, Tente SM, Freitas BCG, Harney JW, Zavacki AM, Bianco AC. Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity. Mol Cell Biol 2007;27:4774-83.
Bianco AC, Kim BW-S. Deiodinases: Implications of the local control of thyroid hormone action. J Clin Invest 2006;116:2571-2579.
Bianco Lab Website:
http://biancolab.bwh.harvard.edu/abianco.html
Contact Information:
Antonio C. Bianco, M.D., Ph.D.
Chief, Thyroid Section Brigham and Women’s Hospital, Associate Professor of Medicine Harvard Medical School
Email: abianco@deiodinase.org
© 2008 Brigham & Women's Hospital
All presentation materials contained in this presetation are the property of Brigham & Women's Hospital and should not be used or duplicated without expressed written concent.
*None of the content on this website should be considered medical or psychological advice. Seahorse Biosciences does not give medical advice or diagnose medical and psychological conditions. Although every effort is made to assure that information on this site is accurate and current, knowledge in the field of cellular bioenergetics is growing rapidly and all data is subject to change without notice.
You should consult with your healthcare professional for specific advice relating to your medical questions or conditions. None of the information, statements and/or links contained on the website are intended to replace the attention or medical instructions from a healthcare professional. Only your practitioner can completely and appropriately assess your situation and make conclusive decisions regarding your care.
