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Seahorse Bioscience
Seahorse Bioscience

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Papers & Posters

2008

"Fission and Selective Fusion Govern Mitochondrial Segregation and Elimination by Autophagy."

Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. (2008).Embo J. [epub ahead of print].

"Advances in Measuring Cellular Bioenergetics using Extracellular Flux."

Ferrick DA, Neilson A, and Beeson C. (2008). Drug Discov Today, in press.

2007

"Metformin-Induced Inhibition of Mitochondrial Complex I Activity Stimulates Fatty Acid Oxidation and Glycolysis While Blunting Glucose Oxidation in C2C12 Myocytes"

Frontiers in Mitochondrial Research
November 25, 2007
Bertinoro, Italy


"ERRgamma Directs and Maintains the Transition to Oxidative Metabolism in the Postnatal Heart."

Alaynick WA, Kondo RP, Xie W, He W, Dufour CR, Downes M, Jonker JW, Giles W, Naviaux RK, Giguere V and Evans RM. (2007).Cell Metab 6:13-24.


"Metformin-Induced Inhibition of Mitochondrial Complex I Activity Stimulates Fatty Acid Oxidation and Glycolysis While Blunting Glucose Oxidation in C2C12 Myocytes"

Molecular & Cellular Bioenergetics
June 17, 2007
Andover, New Hampshire


"Peroxisome Proliferator Activator Receptor Gamma Coactivator-1 Expression is Reduced in Obesity: Potential Pathogenic Role of Saturated Fatty Acids and p38 Mitogen-activated Protein Kinase Activation"

Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC and Patti ME. (2007). Diabetes 56:767-776.


"The Small Polyphenolic Molecule Kaempferol Increases Cellular Energey Expenditure and Thyroid Hormone Activation."

da-Silva WS, Harney JW, Kim BW, Li J, Bianco SD, Crescenzi A, Christoffolete MA, Huang SA and Bianco AC. (2007). J Biol Chem 282:15439-15450.


"The Prolyl Hydroxylase Oxygen-sensing Pathway is Cytoprotective and Allows Maintenance of Mitrochondrial Membrane Potential During Metabolic Inihibition."

Sridharan V, Guichard J, Bailey RM, Kasiganesan H, Beeson C and Wright GL. (2007). Am J Physiol Cell Physiol 292:C719-C728.


"Simultaneous, Kinetic Analysis of Oxygen Consumption and Glycolysis Rate Demonstrates that Inhibition of Acetyl-CoA Carboxylase (ACC) Causes a Sustainable Increase in Fatty Acid Oxidation (FAO) and a Concomitant but Transient Increase in Glycolysis."

Diabetes and Obesity
January 14, 2007
Keystone Colorado


"Multiparameter Metabolic Analysis Reveals a Close Link between Attenuated Mitochondrial Bioenergetics and Enhanced Glycolysis Dependency in Human Tumor Cells."

Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S and Ferrick DA. (2007). Am J of Physiol Cell Physiol 292:C125-C136.

2006

“2-Deoxyglucose Induces a Metabolic Switch to Mitochondrial Oxidative Energy Metabolism Resulting in Sensitization to Apoptosis of Glioblastoma Cells”

Gordon Conference
September 10, 2006
Big Sky, Montana


"A Novel, Non-Radioactive Method for Measuring Fatty Acid Oxidation and Cellular Metabolism in C2C12 Myocytes"

Endocrine Society 2006 Annual Meeting
June 24, 2006
Boston, MA


"Exploration of Mitochondrial Adaptation and Survival Using Extracellular Flux Analysis"

Metabolomics: From Bioenergetics to Apoptosis
April 2, 2006
Snowbird, Utah


"Exploring Bioenergetic Differences Between Aerobic Glycolysis and Fatty Acid Oxidation via Extracellular Flux"

Metabolomics: From Bioenergetics to Apoptosis
April 2, 2006
Snowbird, Utah


“Real-time Metabolic Analysis of Glioblastoma Cells Treated with 2-Deoxyglucose Reveals a Metabolic Switch to Aerobic Energy Metabolism Mediated by HIF-1a”

AACR 2006 Annual Meeting
April 1, 2006
Washington, DC


“Bile Acids Induce Energy Expenditure by Promoting Intracellular Thyroid Hormone Activation”

Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC and Auwerx J. (2006). Nature 439:484-489.


"Extracellular Flux Enables Real-time, Non-invasive Measurements of Cellular Metabolism"

LabAutomation 2006
January 22, 2006
Palm Springs, CA

2005

"Extracellular Flux as an Indicator of Cellular Metabolism"

NAASO Annual Meeting
October 15, 2005
Vancouver, British Columbia


"A Novel Assay for Profiling Metabolic Changes Mediated by HIF-1a in Cancer Cells"

Tumor Metabolism Summit
September 19, 2005
Genoa, Italy


"A Non-destructive, Multi-analyte, Time-resolved Technology for Sensing Metabolic Changes in Cancer Cells"

American Association for Cancer Research
April 19, 2005
Anaheim, CA

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