Publications with Seahorse XF Data

Aging

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• Ethanol withdrawal hastens the aging of cytochrome c oxidase

  Jung M E, Ju X, Metzger D B and Simpkins J W

  Neurobiol Aging; 2012 Mar 1. 33 (3):618.e21-32.

• ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome

  Grunewald A, Arns B, Seibler P, Rakovic A, Munchau A, Ramirez A, Sue C M and Klein C

  Neurobiol Aging. 2012 Jan 30; [Epub ahead of print].

• The role of nuclear lamin B1 in cell proliferation and senescence

  Shimi T, Butin-Israeli V, Adam S A, Hamanaka R B, Goldman A E, Lucas C A, Shumaker D K, Kosak S T, Chandel N S and Goldman R D

  Genes Dev; 2011 Dec 15. 25 (24):2579-2593.

• Identification and characterization of a functional mitochondrial angiotensin system

  Abadir P M, Foster D B, Crow M, Cooke C A, Rucker J J, Jain A, Smith B J, Burks T N, Cohn R D, Fedarko N S, Carey R M, O'Rourke B and Walston J D

  Proc Natl Acad Sci U S A; 2011 Sep 6. 108 (36):14849-14854.

• Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3

  Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E

  J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.

• Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes

  Choi S W, Gerencser A A, Lee D W, Rajagopalan S, Nicholls D G, Andersen J K and Brand M D

  J Neurosci; 2011 Mar 23. 31 (12):4524-4534.

• Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts

  Zhang Y, Zhang H M, Shi Y, Lustgarten M, Li Y, Qi W, Zhang B X and Van Remmen H

  Free Radic Biol Med; 2010 Nov 1. 49 (8):1255-1262.

• Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL

  Civitarese A E, MacLean P S, Carling S, Kerr-Bayles L, McMillan R P, Pierce A, Becker T C, Moro C, Finlayson J, Lefort N, Newgard C B, Mandarino L, Cefalu W, Walder K, Collier G R, Hulver M W, Smith S R and Ravussin E

  Cell Metab; 2010 May 5. 11 (5):412-426.

• Bmi1 regulates mitochondrial function and the DNA damage response pathway

  Liu J, Cao L, Chen J, Song S, Lee I H, Quijano C, Liu H, Keyvanfar K, Chen H, Cao L Y, Ahn B H, Kumar N G, Rovira, II, Xu X L, van Lohuizen M, Motoyama N, Deng C X and Finkel T

  Nature; 2009 May 21. 459 (7245):387-392.

• Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

  Wu J J, Quijano C, Chen E, Liu H, Cao L, Fergusson M M, Rovira, II, Gutkind S, Daniels M P, Komatsu M and Finkel T

  Aging (Albany NY); 2009 Apr 1. 1 (4):425-437.

Cancer

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• Bezielle Selectively Targets Mitochondria of Cancer Cells to Inhibit Glycolysis and OXPHOS

  Chen V, Staub R E, Fong S, Tagliaferri M, Cohen I and Shtivelman E

  PLoS One. 2012 Feb 10; [Epub ahead of print].

• Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1

  Wernstedt Asterholm I, Mundy D I, Weng J, Anderson R G and Scherer P E

  Cell Metab; 2012 Feb 8. 15 (2):171-185.

• Dysregulation of Ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma

  Ren L, Hong S H, Chen Q R, Briggs J, Cassavaugh J, Srinivasan S, Lizardo M M, Mendoza A, Xia A Y, Avadhani N, Khan J and Khanna C

  Cancer Res. 2012 Feb 2; [Epub ahead of print].

• Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

  Yang J, Staples O, Thomas L W, Briston T, Robson M, Poon E, Simoes M L, El-Emir E, Buffa F M, Ahmed A, Annear N P, Shukla D, Pedley B, Maxwell P H, Harris A L and Ashcroft M

  J Clin Invest; 2012 Feb 1. 122 (2):600-11.

• Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status

  Sandulache V C, Skinner H D, Ow T J, Zhang A, Xia X, Luchak J M, Wong L J, Pickering C R, Zhou G and Myers J N

  Cancer; 2012 Feb 1. 118 (3):711-21.

• Mesenchymal Stromal Cells Protect Cancer Cells From ROS-induced Apoptosis and Enhance the Warburg Effect by Secreting STC1

  Ohkouchi S, Block G J, Katsha A M, Kanehira M, Ebina M, Kikuchi T, Saijo Y, Nukiwa T and Prockop D J

  Mol Ther; 2012 Feb 1. 20 (2):417-23.

• Akt3 controls VEGF secretion and angiogenesis in ovarian cancer cells

  Liby T A, Spyropoulos P, Lindner H B, Eldridge J, Beeson C, Hsu T and Muise-Helmericks R C

  Int J Cancer; 2012 Feb 1. 130 (3):532-43.

• Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells

  Chiu W H, Luo S J, Chen C L, Cheng J H, Hsieh C Y, Wang C Y, Huang W C, Su W C and Lin C F

  Biochem Pharmacol. 2012 Jan 20; [Epub ahead of print].

• Identification and analysis of the active phytochemicals from the anti-cancer botanical extract bezielle

  Chen V, Staub R E, Baggett S, Chimmani R, Tagliaferri M, Cohen I and Shtivelman E

  PLoS One. 2012 Jan 17; [Epub ahead of print].

• Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts

  Fabian C, Koetz L, Favaro E, Indraccolo S, Mueller-Klieser W and Sattler U G

  FEBS J. 2012 Jan 12; [Epub ahead of print].

• Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells

  Zhou Y, Tozzi F, Chen J, Fan F, Xia L, Wang J, Gao G, Zhang A, Xia X, Brasher H, Widger W, Ellis L M and Weihua Z

  Cancer Res; 2012 Jan 1. 72 (1):304-14.

• Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model

  Ibrahim-Hashim A, Wojtkowiak J W, Ribeiro M d L C, Estrella V, Bailey K M, Cornnell H H, Gatenby R A and Gillies R J

  J Cancer Sci Ther S1; 2011 Nov 19.

• Targeting chaperone-mediated autophagy in cancer

  Thorburn A and Debnath J

  Sci Transl Med; 2011 Nov 16. 3 (109):109ps145.

• Chaperone-mediated autophagy is required for tumor growth

  Kon M, Kiffin R, Koga H, Chapochnick J, Macian F, Varticovski L and Cuervo A M

  Sci Transl Med; 2011 Nov 16. 3 (109):109ra117.

• Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels

  Wang X and Moraes C T

  Mol Oncol; 2011 Oct 1. 5 (5):399-409.

• NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

  Mauro C, Leow S C, Anso E, Rocha S, Thotakura A K, Tornatore L, Moretti M, De Smaele E, Beg A A, Tergaonkar V, Chandel N S and Franzoso G

  Nat Cell Biol; 2011 Oct 1. 13 (10):1272-1279.

• Involvement of mitophagy in oncogenic K-Ras-induced transformation: Overcoming a cellular energy deficit from glucose deficiency

  Kim J H, Kim H Y, Lee Y K, Yoon Y S, Xu W G, Yoon J K, Choi S E, Ko Y G, Kim M J, Lee S J, Wang H J and Yoon G

  Autophagy; 2011 Oct 1. 7 (10):1187-1198.

• Metabolic state of glioma stem cells and nontumorigenic cells

  Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel P S and Pajonk F

  Proc Natl Acad Sci U S A; 2011 Sep 20. 108 (38):16062-16067.

• The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

  Tong W H, Sourbier C, Kovtunovych G, Jeong S Y, Vira M, Ghosh M, Romero V V, Sougrat R, Vaulont S, Viollet B, Kim Y S, Lee S, Trepel J, Srinivasan R, Bratslavsky G, Yang Y, Linehan W M and Rouault T A

  Cancer Cell; 2011 Sep 13. 20 (3):315-327.

• Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism

  Cvrljevic A N, Akhavan D, Wu M, Martinello P, Furnari F B, Johnston A J, Guo D, Pike L, Cavenee W K, Scott A M, Mischel P S, Hoogenraad N J and Johns T G

  J Cell Sci; 2011 Sep 1. 124 (Pt 17):2938-2950.

• Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

  Frezza C, Zheng L, Folger O, Rajagopalan K N, Mackenzie E D, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A, Kalna G, Tomlinson I P, Pollard P J, Watson D G, Deberardinis R J, Shlomi T, Ruppin E and Gottlieb E

  Nature; 2011 Aug 17. 477 (7363):225-8.

• Withaferin a-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species

  Hahm E R, Moura M B, Kelley E E, Van Houten B, Shiva S and Singh S V

  PLoS One. 2011 Aug 10; [Epub ahead of print].

• Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

  Chan D A, Sutphin P D, Nguyen P, Turcotte S, Lai E W, Banh A, Reynolds G E, Chi J T, Wu J, Solow-Cordero D E, Bonnet M, Flanagan J U, Bouley D M, Graves E E, Denny W A, Hay M P and Giaccia A J

  Sci Transl Med; 2011 Aug 3. 3 (94):94ra70.

• Akt-dependent glucose metabolism promotes mcl-1 synthesis to maintain cell survival and resistance to bcl-2 inhibition

  Coloff J L, Macintyre A N, Nichols A G, Liu T, Gallo C A, Plas D R and Rathmell J C

  Cancer Res; 2011 Aug 1. 71 (15):5204-5213.

• Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

  Parkhitko A, Myachina F, Morrison T A, Hindi K M, Auricchio N, Karbowniczek M, Wu J J, Finkel T, Kwiatkowski D J, Yu J J and Henske E P

  Proc Natl Acad Sci U S A; 2011 Jul 26. 108 (30):12455-12460.

• E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells

  Hatchi E, Rodier G, Lacroix M, Caramel J, Kirsh O, Jacquet C, Schrepfer E, Lagarrigue S, Linares L K, Lledo G, Tondeur S, Dubus P, Sardet C and Le Cam L

  J Exp Med; 2011 Jul 4. 208 (7):1403-1417.

• The selective growth inhibition of oral cancer by iron core-gold shell nanoparticles through mitochondria-mediated autophagy

  Wu Y N, Yang L X, Shi X Y, Li I C, Biazik J M, Ratinac K R, Chen D H, Thordarson P, Shieh D B and Braet F

  Biomaterials; 2011 Jul 1. 32 (20):4565-4573.

• Dietary Fish Oil Promotes Colonic Apoptosis and Mitochondrial Proton Leak in Oxidatively Stressed Mice

  Fan Y Y, Ran Q, Toyokuni S, Okazaki Y, Callaway E S, Lupton J R and Chapkin R S

  Cancer Prev Res (Phila); 2011 Jul 1. 4 (18):1267-1274.

• Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3

  Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E

  J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.

• Mitochondrial Dysfunction Impairs Tumor Suppressor p53 Expression/Function

  Compton S, Kim C, Griner N B, Potluri P, Scheffler I E, Sen S, Jerry D J, Schneider S and Yadava N

  J Biol Chem; 2011 Jun 10. 286 (23):20297-20312.

• Mitochondrial Phosphatase PTPMT1 Is Essential for Cardiolipin Biosynthesis

  Zhang J, Guan Z, Murphy A N, Wiley S E, Perkins G A, Worby C A, Engel J L, Heacock P, Nguyen O K, Wang J H, Raetz C R, Dowhan W and Dixon J E

  Cell Metab; 2011 Jun 8. 13 (6):690-700.

• High-mobility group box 1 is essential for mitochondrial quality control

  Tang D, Kang R, Livesey K M, Kroemer G, Billiar T R, Van Houten B, Zeh H J, 3rd and Lotze M T

  Cell Metab; 2011 Jun 8. 13 (6):701-711.

• AMPK regulates metabolism and survival in response to ionizing radiation

  Zannella V E, Cojocari D, Hilgendorf S, Vellanki R N, Chung S, Wouters B G and Koritzinsky M

  Radiother Oncol; 2011 Jun 1. 99 (3):293-299.

• Kinase Suppressor of Ras 1 (KSR1) Regulates PGC1{alpha} and Estrogen-Related Receptor {alpha} To Promote Oncogenic Ras-Dependent Anchorage-Independent Growth

  Fisher K W, Das B, Kortum R L, Chaika O V and Lewis R E

  Mol Cell Biol; 2011 Jun 1. 31 (12):2453-2461.

• Bax Supports the Mitochondrial Network, Promoting Bioenergetics in Non-Apoptotic Cells

  Boohaker R J, Zhang G, Carlson A L, Nemec K N and Khaled A R

  Am J Physiol Cell Physiol; 2011 Jun 1. 300 (6):466-478.

• Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

  Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole R N, Pandey A and Semenza G L

  Cell; 2011 May 27. 145 (5):732-744.

• Pancreatic cancers require autophagy for tumor growth

  Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel J M, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai O S, Doglioni C, Bardeesy N and Kimmelman A C

  Genes Dev; 2011 Apr 1. 25 (7):717-729.

• Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells

  Benitez A C, Dai Z, Mann H H, Reeves R S, Margineantu D H, Gooley T A, Groh V and Spies T

  Proc Natl Acad Sci U S A; 2011 Mar 8. 108 (10):4081-4086.

• Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC

  Yamasaki T, Tran T A, Oz O K, Raj G V, Schwarz R E, Deberardinis R J, Zhang X and Brugarolas J

  Nat Rev Urol; 2011 Mar 1. 8 (3):165-171.

• Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

  Guo J Y, Chen H Y, Mathew R, Fan J, Strohecker A M, Karsli-Uzunbas G, Kamphorst J J, Chen G, Lemons J M, Karantza V, Coller H A, Dipaola R S, Gelinas C, Rabinowitz J D and White E

  Genes Dev; 2011 Mar 1. 25 (5):460-470.

• Development of chromanes as novel inhibitors of the uncoupling proteins

  Rial E, Rodriguez-Sanchez L, Aller P, Guisado A, Mar Gonzalez-Barroso M, Gallardo-Vara E, Redondo-Horcajo M, Castellanos E, Fernandez de la Pradilla R and Viso A

  Chem Biol; 2011 Feb 25. 18 (2):264-274.

• The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil

  Sanchez-Arago M and Cuezva J M

  J Transl Med; 2011 Feb 10. 9 (19)

• On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate

  Seth P, Grant A, Tang J, Vinogradov E, Wang X, Lenkinski R and Sukhatme V P

  Neoplasia; 2011 Jan 1. 13 (1):60-71.

• Cytoprotective effect of gamma-tocopherol against tumor necrosis factor alpha induced cell dysfunction in L929 cells

  Olah G, Modis K, Gero D, Suzuki K, Dewitt D, Traber D L and Szabo C

  Int J Mol Med; 2011 Jan 1. 28 (5):711-720.

• Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain

  Oliva C R, Nozell S E, Diers A, McClugage S G, 3rd, Sarkaria J N, Markert J M, Darley-Usmar V M, Bailey S M, Gillespie G Y, Landar A and Griguer C E

  J Biol Chem; 2010 Dec 17. 285 (51):39759-39767.

• CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitation

  Chen V and Shtivelman E

  Cell Cycle; 2010 Dec 15. 9 (24):4941-4953.

• Leptin Receptor Signaling Supports Cancer Cell Metabolism through Suppression of Mitochondrial Respiration in Vivo

  Park J, Kusminski C M, Chua S C and Scherer P E

  Am J Pathol; 2010 Dec 1. 177 (6):3133-3144.

• Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

  Pike L S, Smift A L, Croteau N J, Ferrick D A and Wu M

  Biochim Biophys Acta. 2010 Nov 12; [Epub ahead of print].

• Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts

  Graves J A, Rothermund K, Wang T, Qian W, Van Houten B and Prochownik E V

  PLoS One; 2010 Oct 28. 5 (10):e13717.

• Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents

  Mailloux R J, Adjeitey C N and Harper M E

  PLoS One; 2010 Oct 13. 5 (10):e13289.

• Preclinical Evaluation of Novel Triphenylphosphonium Salts with Broad-Spectrum Activity

  Millard M, Pathania D, Shabaik Y, Taheri L, Deng J and Neamati N

  PLoS One; 2010 Oct 4. 5 (10):e13131.

• Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells

  Xiao D, Powolny A A, Moura M B, Kelley E E, Bommareddy A, Kim S H, Hahm E R, Normolle D, Van Houten B and Singh S V

  J Biol Chem; 2010 Aug 20. 285 (34):26558-26569.

• Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype

  Sanchez-Cenizo L, Formentini L, Aldea M, Ortega A D, Garcia-Huerta P, Sanchez-Arago M and Cuezva J M

  J Biol Chem; 2010 Aug 13. 285 (33):25308-25313.

• Alterations in bioenergetics due to changes in mitochondrial DNA copy number

  Qian W and Van Houten B

  Methods; 2010 Aug 1. 51 (4):452-457.

• Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells

  Delgado T, Carroll P A, Punjabi A S, Margineantu D, Hockenbery D M and Lagunoff M

  Proceedings of the National Academy of Sciences; 2010 Jun 8. 107 (23):10696-10701.

• Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

  Weinberg F, Hamanaka R, Wheaton W W, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu G M, Budinger G R and Chandel N S

  Proc Natl Acad Sci U S A; 2010 May 11. 107 (19):8788-8793.

• Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose

  Blouin M J, Zhao Y, Zakikhani M, Algire C, Piura E and Pollak M

  Cancer Lett; 2010 Mar 28. 289 (2):246-253.

• Differential metabolic responses to pluronic in MDR and non-MDR cells: a novel pathway for chemosensitization of drug resistant cancers

  Alakhova D Y, Rapoport N Y, Batrakova E V, Timoshin A A, Li S, Nicholls D, Alakhov V Y and Kabanov A V

  J Control Release; 2010 Feb 25. 142 (1):89-100.

• UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

  Yang Y, Valera V A, Padilla-Nash H M, Sourbier C, Vocke C D, Vira M A, Abu-Asab M S, Bratslavsky G, Tsokos M, Merino M J, Pinto P A, Srinivasan R, Ried T, Neckers L and Linehan W M

  Cancer Genet Cytogenet; 2010 Jan 1. 196 (1):45-55.

• Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104

  Cairns R A, Bennewith K L, Graves E E, Giaccia A J, Chang D T and Denko N C

  Clin Cancer Res; 2009 Dec 1. 15 (23):7170-7174.

• Polo-like kinases mediate cell survival in mitochondrial dysfunction

  Matsumoto T, Wang P Y, Ma W, Sung H J, Matoba S and Hwang P M

  Proc Natl Acad Sci U S A; 2009 Aug 25. 106 (34):14542-14546.

• Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype

  de Groof A J, te Lindert M M, van Dommelen M M, Wu M, Willemse M, Smift A L, Winer M, Oerlemans F, Pluk H, Fransen J A and Wieringa B

  Mol Cancer; 2009 Jul 31. 8 (1):54.

• Methods in Cancer Metabolism: Real-Time Measurement of Mitochondrial Respiration and Glycolysis Rates of Cancer Cells in a Microplate

  Wu M

  Am. Assoc. Cancer Res. Education Book; 2009 Apr 1. :295-300.

• LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

  Xie H, Valera V A, Merino M J, Amato A M, Signoretti S, Linehan W M, Sukhatme V P and Seth P

  Mol Cancer Ther; 2009 Mar 1. 8 (3):626-635.

• Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells

  Slomiany M G, Grass G D, Robertson A D, Yang X Y, Maria B L, Beeson C and Toole B P

  Cancer Res; 2009 Feb 15. 69 (4):1293-1301.

• Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

  Wu M, Neilson A, Swift A L, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S and Ferrick D A

  Am J Physiol Cell Physiol; 2007 Jan 1. 292 (1):C125-136.

Cardiovascular

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• Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle's cycle

  Fang Y H, Piao L, Hong Z, Toth P T, Marsboom G, Bache-Wiig P, Rehman J and Archer S L

  J Mol Med (Berl); 2012 Jan 1. 90 (1):31-43.

• Molecular Analysis of Mitochondrial Compromise in Rodent Cardiomyocytes Exposed Long Term to Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

  Liu Y, Nguyen P, Baris T Z and Poirier M C

  Cardiovasc Toxicol. 2011 Dec 15; [Epub ahead of print].

• Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction

  Szanto M, Rutkai I, Hegedus C, Czikora A, Rozsahegyi M, Kiss B, Virag L, Gergely P, Toth A and Bai P

  Cardiovasc Res; 2011 Dec 1. 92 (3):430-438.

• Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt

  Mullen P J, Zahno A, Lindinger P, Maseneni S, Felser A, Krahenbuhl S and Brecht K

  Biochim Biophys Acta; 2011 Dec 1. 1813 (12):2079-87.

• GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFbeta signaling

  Willaert A, Khatri S, Callewaert B L, Coucke P J, Crosby S D, Lee J G, Davis E C, Shiva S, Tsang M, De Paepe A and Urban Z

  Hum Mol Genet. 2011 Nov 24; [Epub ahead of print].

• The Transcriptional Coactivators, PGC-1? and ?, Cooperate to Maintain Cardiac Mitochondrial Function During the Early Stages of Insulin Resistance

  Mitra R, Nogee D P, Zechner J F, Yea K, Gierasch C M, Kovacs A, Medeiros D M, Kelly D P and Duncan J G

  J Mol Cell Cardiol. 2011 Oct 20; [Epub ahead of print].

• Identification and characterization of a functional mitochondrial angiotensin system

  Abadir P M, Foster D B, Crow M, Cooke C A, Rucker J J, Jain A, Smith B J, Burks T N, Cohn R D, Fedarko N S, Carey R M, O'Rourke B and Walston J D

  Proc Natl Acad Sci U S A; 2011 Sep 6. 108 (36):14849-14854.

• Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells

  Diers A R, Broniowska K A, Darley-Usmar V M and Hogg N

  Am J Physiol Heart Circ Physiol; 2011 Sep 1. 301 (3):H803-812.

• Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function

  Suzuki K, Olah G, Modis K, Coletta C, Kulp G, Gero D, Szoleczky P, Chang T, Zhou Z, Wu L, Wang R, Papapetropoulos A and Szabo C

  Proc Natl Acad Sci U S A; 2011 Aug 16. 108 (33):13829-13834.

• Mitochondrial Transporter ATP Binding Cassette Mitochondrial Erythroid Is a Novel Gene Required for Cardiac Recovery After Ischemia/Reperfusion

  Liesa M, Luptak I, Qin F, Hyde B B, Sahin E, Siwik D A, Zhu Z, Pimentel D R, Xu X J, Ruderman N B, Huffman K D, Doctrow S R, Richey L, Colucci W S and Shirihai O S

  Circulation; 2011 Aug 16. 124 (7):806-813.

• Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in human adipocytes by activating AMPK

  Souza S C, Chau M D, Yang Q, Gauthier M S, Clairmont K B, Wu Z, Gromada J and Dole W P

  Biochem Biophys Res Commun; 2011 Jul 8. 410 (3):398-403.

• Mitochondria determine the differentiation potential of cardiac mesoangioblasts

  San Martin N, Cervera A M, Cordova C, Covarello D, McCreath K J and Galvez B G

  Stem Cells; 2011 Jul 1. 29 (7):1064-1074.

• Bioenergetic function in cardiovascular cells: The importance of the reserve capacity and its biological regulation

  Sansbury B E, Jones S P, Riggs D W, Darley-Usmar V M and Hill B G

  Chem Biol Interact; 2011 May 30. 191 (1-3):288-295.

• Responses of hypertrophied myocytes to reactive species: implications for glycolysis and electrophile metabolism

  Sansbury B E, Riggs D W, Brainard R E, Salabei J K, Jones S P and Hill B G

  Biochem J; 2011 Apr 15. 435 (2):519-528.

• Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy

  Moslehi J, Minamishima Y A, Shi J, Neuberg D, Charytan D M, Padera R F, Signoretti S, Liao R and Kaelin W G, Jr.

  Circulation; 2010 Sep 7. 122 (10):1004-1016.

• Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factor

  Perez J, Hill B G, Benavides G A, Dranka B P and Darley-Usmar V M

  Biochem J; 2010 Jun 1. 428 (2):255-267.

• Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species

  Dranka B P, Hill B G and Darley-Usmar V M

  Free Radic Biol Med; 2010 Apr 1. 48 (7):905-914.

• Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

  Gohil V M, Sheth S A, Nilsson R, Wojtovich A P, Lee J H, Perocchi F, Chen W, Clish C B, Ayata C, Brookes P S and Mootha V K

  Nat Biotechnol; 2010 Mar 1. 28 (3):249-255.

• Regulation of vascular smooth muscle cell bioenergetic function by protein glutathiolation

  Hill B G, Higdon A N, Dranka B P and Darley-Usmar V M

  Biochim Biophys Acta; 2010 Feb 1. 1797 (2):285-295.

• Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal

  Hill B G, Dranka B P, Zou L, Chatham J C and Darley-Usmar V M

  Biochem J; 2009 Nov 15. 424 (1):99-107.

• MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2

  Chan S Y, Zhang Y Y, Hemann C, Mahoney C E, Zweier J L and Loscalzo J

  Cell Metab; 2009 Oct 1. 10 (4):273-284.

• O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration

  Sridharan V, Guichard J, Li C Y, Muise-Helmericks R, Beeson C C and Wright G L

  Am J Physiol Cell Physiol; 2008 Jul 1. 295 (1):C29-37.

• Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats

  Simonides W S, Mulcahey M A, Redout E M, Muller A, Zuidwijk M J, Visser T J, Wassen F W, Crescenzi A, da-Silva W S, Harney J, Engel F B, Obregon M J, Larsen P R, Bianco A C and Huang S A

  J Clin Invest; 2008 Mar 1. 118 (3):975-983.

• ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart

  Alaynick W A, Kondo R P, Xie W, He W, Dufour C R, Downes M, Jonker J W, Giles W, Naviaux R K, Giguere V and Evans R M

  Cell Metab; 2007 Jul 1. 6 (1):13-24.

• The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition

  Sridharan V, Guichard J, Bailey R M, Kasiganesan H, Beeson C and Wright G L

  Am J Physiol Cell Physiol; 2007 Feb 1. 292 (2):C719-728.

Cell Physiology

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• Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress

  Modis K, Gero D, Erdelyi K, Szoleczky P, Dewitt D and Szabo C

  Biochem Pharmacol; 2012 Mar 1. 83 (5):633-643.

• Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1

  Wernstedt Asterholm I, Mundy D I, Weng J, Anderson R G and Scherer P E

  Cell Metab; 2012 Feb 8. 15 (2):171-185.

• SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice

  Seifert E L, Caron A Z, Morin K, Coulombe J, Hong He X, Jardine K, Dewar-Darch D, Boekelheide K, Harper M E and McBurney M W

  FASEB J; 2012 Feb 1. 26 (2):555-66.

• Role of mitofusin 2 in the renal stress response

  Gall J M, Wang Z, Liesa M, Molina A, Havasi A, Schwartz J H, Shirihai O, Borkan S C and Bonegio R G

  PLoS One; 2012 Jan 26. 7 (1):e31074.

• Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: The protective role of autophagy

  Higdon A N, Benavides G A, Chacko B K, Ouyang X, Johnson M S, Landar A, Zhang J and Darley-Usmar V M

  Am J Physiol Heart Circ Physiol. 2012 Jan 13; [Epub ahead of print].

• Integrin-Dependent Akt1 Activation Regulates PGC-1 Expression and Fatty Acid Oxidation

  Beeson C C, Beeson G C, Buff H, Eldridge J, Zhang A, Seth A, Demcheva M, Vournakis J N and Muise-Helmericks R C

  J Vasc Res. 2012 Jan 13; [Epub ahead of print].

• C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome

  Rorbach J, Gammage P A and Minczuk M

  Nucleic Acids Res. 2012 Jan 11; [Epub ahead of print].

• Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells

  Yin F, Sancheti H and Cadenas E

  Biochim Biophys Acta; 2011 Dec 16. 1817 (3):401-409.

• The role of nuclear lamin B1 in cell proliferation and senescence

  Shimi T, Butin-Israeli V, Adam S A, Hamanaka R B, Goldman A E, Lucas C A, Shumaker D K, Kosak S T, Chandel N S and Goldman R D

  Genes Dev; 2011 Dec 15. 25 (24):2579-2593.

• The nuclear receptor PPARbeta/delta programs muscle glucose metabolism in cooperation with AMPK and MEF2

  Gan Z, Burkart-Hartman E M, Han D H, Finck B, Leone T C, Smith E Y, Ayala J E, Holloszy J and Kelly D P

  Genes Dev; 2011 Dec 15. 25 (24):2619-30.

• Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

  Wang H, Sreenevasan U, Hu H, Saladino A, Polster B M, Lund L M, Gong D W, Stanley W C and Sztalryd C

  J Lipid Res; 2011 Dec 1. 52 (12):2159-2168.

• Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction

  Szanto M, Rutkai I, Hegedus C, Czikora A, Rozsahegyi M, Kiss B, Virag L, Gergely P, Toth A and Bai P

  Cardiovasc Res; 2011 Dec 1. 92 (3):430-438.

• A critical role of mitochondrial phosphatase ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells

  Shen J, Liu X, Yu W M, Liu J, Groot Nibbelink M, Guo C, Finkel T and Qu C K

  Mol Cell Biol; 2011 Dec 1. 31 (24):4902-4916.

• NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

  Yamamoto H, Williams E G, Mouchiroud L, Canto C, Fan W, Downes M, Heligon C, Barish G D, Desvergne B, Evans R M, Schoonjans K and Auwerx J

  Cell; 2011 Nov 11. 147 (4):827-839.

• Assessing bioenergetic function in response to oxidative stress by metabolic profiling

  Dranka B P, Benavides G A, Diers A R, Giordano S, Zelickson B R, Reily C, Zou L, Chatham J C, Hill B G, Zhang J, Landar A and Darley-Usmar V M

  Free Radic Biol Med; 2011 Nov 1. 51 (9):1621-1635.

• The Transcriptional Coactivators, PGC-1? and ?, Cooperate to Maintain Cardiac Mitochondrial Function During the Early Stages of Insulin Resistance

  Mitra R, Nogee D P, Zechner J F, Yea K, Gierasch C M, Kovacs A, Medeiros D M, Kelly D P and Duncan J G

  J Mol Cell Cardiol. 2011 Oct 20; [Epub ahead of print].

• The PGC-1{alpha}-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes

  Philp A, Belew M Y, Evans A, Pham D, Sivia I, Chen A, Schenk S and Baar K

  Am J Physiol Regul Integr Comp Physiol; 2011 Oct 1. 301 (4):R864-872.

• NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

  Mauro C, Leow S C, Anso E, Rocha S, Thotakura A K, Tornatore L, Moretti M, De Smaele E, Beg A A, Tergaonkar V, Chandel N S and Franzoso G

  Nat Cell Biol; 2011 Oct 1. 13 (10):1272-1279.

• Apoptosis induced by persistent single-strand breaks in the mitochondrial genome: Critical role of EXOG (5' EXO/Endonuclease) in their repair

  Tann A W, Boldogh I, Meiss G, Qian W, Van Houten B, Mitra S and Szczesny B

  J Biol Chem; 2011 Sep 16. 286 (37):31975-31983.

• Uncoupling proteins and the control of mitochondrial reactive oxygen species production

  Mailloux R J and Harper M E

  Free Radic Biol Med; 2011 Sep 15. 51 (6):1106-1115.

• Identification and characterization of a functional mitochondrial angiotensin system

  Abadir P M, Foster D B, Crow M, Cooke C A, Rucker J J, Jain A, Smith B J, Burks T N, Cohn R D, Fedarko N S, Carey R M, O'Rourke B and Walston J D

  Proc Natl Acad Sci U S A; 2011 Sep 6. 108 (36):14849-14854.

• PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria

  Rorbach J, Nicholls T J and Minczuk M

  Nucleic Acids Res; 2011 Sep 1. 39 (17):7750-7763.

• The Rate of Oxygen Utilization by Cells

  Wagner B A, Venkataraman S and Buettner G R

  Free Radical Biology and Medicine; 2011 Aug 1. 51 (3):700-712.

• Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration

  Mailloux R J, Dumouchel T, Aguer C, deKemp R, Beanlands R and Harper M E

  Biochem J; 2011 Jul 15. 437 (2):301-311.

• Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

  Baughman J M, Perocchi F, Girgis H S, Plovanich M, Belcher-Timme C A, Sancak Y, Bao X R, Strittmatter L, Goldberger O, Bogorad R L, Koteliansky V and Mootha V K

  Nature; 2011 Jun 19. 476 (7360):341-345.

• Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3

  Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E

  J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.

• Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein

  Bernier M, Paul R K, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He H J, Armour S M, Hubbard B P, Bohr V A, Wang L, Zong Y, Sinclair D A and de Cabo R

  J Biol Chem; 2011 Jun 3. 286 (22):19270-19279.

• Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation

  Chambers J W and Lograsso P V

  J Biol Chem; 2011 May 6. 286 (18):16052-16062.

• Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion

  Wiederkehr A, Szanda G, Akhmedov D, Mataki C, Heizmann C W, Schoonjans K, Pozzan T, Spat A and Wollheim C B

  Cell Metab; 2011 May 4. 13 (5):601-611.

• TEFM (c17orf42) is necessary for transcription of human mtDNA

  Minczuk M, He J, Duch A M, Ettema T J, Chlebowski A, Dzionek K, Nijtmans L G, Huynen M A and Holt I J

  Nucleic Acids Res; 2011 May 1. 39 (10):4284-4299.

• PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

  Bai P, Canto C, Oudart H, Brunyanszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper R H, Schoonjans K, Schreiber V, Sauve A A, Menissier-de Murcia J and Auwerx J

  Cell Metab; 2011 Apr 6. 13 (4):461-468.

• Assessing mitochondrial dysfunction in cells

  Brand M D and Nicholls D

  Biochem J; 2011 Mar 29. 435 (1):297-312.

• Glutamate Transport Decreases Mitochondrial pH and Modulates Oxidative Metabolism in Astrocytes

  Azarias G, Perreten H, Lengacher S, Poburko D, Demaurex N, Magistretti P J and Chatton J Y

  J Neurosci; 2011 Mar 9. 31 (10):3550-3559.

• Exercise and PGC-1alpha-independent synchronization of type I muscle metabolism and vasculature by ERRgamma

  Narkar V A, Fan W, Downes M, Yu R T, Jonker J W, Alaynick W A, Banayo E, Karunasiri M S, Lorca S and Evans R M

  Cell Metab; 2011 Mar 2. 13 (3):283-293.

• A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells

  Birket M J, Orr A L, Gerencser A A, Madden D T, Vitelli C, Swistowski A, Brand M D and Zeng X

  J Cell Sci; 2011 Feb 1. 124 (Pt 3):348-358.

• ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function

  Darshi M, Mendiola V L, Mackey M R, Murphy A N, Koller A, Perkins G A, Ellisman M H and Taylor S S

  J Biol Chem; 2011 Jan 28. 286 (4):2918-2932.

• Cytoprotective effect of gamma-tocopherol against tumor necrosis factor alpha induced cell dysfunction in L929 cells

  Olah G, Modis K, Gero D, Suzuki K, Dewitt D, Traber D L and Szabo C

  Int J Mol Med; 2011 Jan 1. 28 (5):711-720.

• The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

  Gurumurthy S, Xie S Z, Alagesan B, Kim J, Yusuf R Z, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park P J, Shirihai O S, Scadden D T and Bardeesy N

  Nature; 2010 Dec 2. 468 (7324):659-663.

• Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts

  Zhang Y, Zhang H M, Shi Y, Lustgarten M, Li Y, Qi W, Zhang B X and Van Remmen H

  Free Radic Biol Med; 2010 Nov 1. 49 (8):1255-1262.

• Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

  Akhmedov D, Braun M, Mataki C, Park K S, Pozzan T, Schoonjans K, Rorsman P, Wollheim C B and Wiederkehr A

  FASEB J; 2010 Nov 1. 24 (11):4613-4626.

• Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration

  Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro J B, Adelmant G O, Marto J A, Rhee K, Tisdale S, Danial N, Benarafa C, Orduna A and Anderson P

  Biochem Biophys Res Commun; 2010 Oct 22. 401 (3):440-446.

• SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells

  Nasrin N, Wu X, Fortier E, Feng Y, Bare O C, Chen S, Ren X, Wu Z, Streeper R S and Bordone L

  J Biol Chem; 2010 Oct 15. 285 (42):31995-32002.

• MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake

  Perocchi F, Gohil V M, Girgis H S, Bao X R, McCombs J E, Palmer A E and Mootha V K

  Nature; 2010 Sep 16. 467 (7313):291-296.

• Alterations in bioenergetics due to changes in mitochondrial DNA copy number

  Qian W and Van Houten B

  Methods; 2010 Aug 1. 51 (4):452-457.

• Pyruvate suppresses PGC1α expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes

  Philp A, Perez-Schindler J, Green C, Hamilton D L and Baar K

  Am J Physiol Cell Physiol; 2010 Aug 1. 299 (2):C240-250.

• Bioenergetic characterization of mouse podocytes

  Abe Y, Sakairi T, Kajiyama H, Shrivastav S, Beeson C and Kopp J B

  Am J Physiol Cell Physiol; 2010 Aug 1. 299 (2):C464-476.

• Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria

  Cardenas C, Miller R A, Smith I, Bui T, Molgo J, Muller M, Vais H, Cheung K H, Yang J, Parker I, Thompson C B, Birnbaum M J, Hallows K R and Foskett J K

  Cell; 2010 Jul 23. 142 (2):270-283.

• Wnt signaling regulates mitochondrial physiology and insulin sensitivity

  Yoon J C, Ng A, Kim B H, Bianco A, Xavier R J and Elledge S J

  Genes Dev; 2010 Jul 15. 24 (14):1507-1518.

• Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1α pathway

  Chau M D, Gao J, Yang Q, Wu Z and Gromada J

  Proc Natl Acad Sci U S A; 2010 Jul 13. 107 (28):12553-12558.

• Forward operation of adenine nucleotide translocase during F0F1-ATPase reversal: critical role of matrix substrate-level phosphorylation

  Chinopoulos C, Gerencser A A, Mandi M, Mathe K, Torocsik B, Doczi J, Turiak L, Kiss G, Konrad C, Vajda S, Vereczki V, Oh R J and Adam-Vizi V

  FASEB J; 2010 Jul 1. 24 (7):2405-2416.

• Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

  Hawley S A, Ross F A, Chevtzoff C, Green K A, Evans A, Fogarty S, Towler M C, Brown L J, Ogunbayo O A, Evans A M and Hardie D G

  Cell Metab; 2010 Jun 9. 11 (6):554-565.

• Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms

  Bao J, Lu Z, Joseph J J, Carabenciov D, Dimond C C, Pang L, Samsel L, McCoy J P, Jr., Leclerc J, Nguyen P, Gius D and Sack M N

  J Cell Biochem; 2010 May 1. 110 (1):238-247.

• Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

  Canto C, Jiang L Q, Deshmukh A S, Mataki C, Coste A, Lagouge M, Zierath J R and Auwerx J

  Cell Metab; 2010 Mar 3. 11 (3):213-219.

• MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2

  Chan S Y, Zhang Y Y, Hemann C, Mahoney C E, Zweier J L and Loscalzo J

  Cell Metab; 2009 Oct 1. 10 (4):273-284.

• Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbα

  Wu N, Yin L, Hanniman E A, Joshi S and Lazar M A

  Genes Dev; 2009 Sep 15. 23 (18):2201-2209.

• Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T

  Amo T, Yadava N, Oh R, Nicholls D G and Brand M D

  Gene; 2008 Mar 31. 411 (40545):69-76.

• Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

  Twig G, Elorza A, Molina A J, Mohamed H, Wikstrom J D, Walzer G, Stiles L, Haigh S E, Katz S, Las G, Alroy J, Wu M, Py B F, Yuan J, Deeney J T, Corkey B E and Shirihai O S

  EMBO J; 2008 Jan 23. 27 (2):433-446.

Immunology

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• Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8(+) T Cell Memory Development

  van der Windt G J, Everts B, Chang C H, Curtis J D, Freitas T C, Amiel E, Pearce E J and Pearce E L

  Immunity; 2012 Jan 27. 36 (1):38-78.

• The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

  Wang R, Dillon C P, Shi L Z, Milasta S, Carter R, Finkelstein D, McCormick L L, Fitzgerald P, Chi H, Munger J and Green D R

  Immunity; 2011 Dec 23. 35 (6):871-882.

• Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3

  Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E

  J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.

• Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

  Bulua A C, Simon A, Maddipati R, Pelletier M, Park H, Kim K Y, Sack M N, Kastner D L and Siegel R M

  J Exp Med; 2011 Mar 14. 208 (3):519-533.

• Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells

  Benitez A C, Dai Z, Mann H H, Reeves R S, Margineantu D H, Gooley T A, Groh V and Spies T

  Proc Natl Acad Sci U S A; 2011 Mar 8. 108 (10):4081-4086.

• The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

  Gurumurthy S, Xie S Z, Alagesan B, Kim J, Yusuf R Z, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park P J, Shirihai O S, Scadden D T and Bardeesy N

  Nature; 2010 Dec 2. 468 (7324):659-663.

• Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration

  Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro J B, Adelmant G O, Marto J A, Rhee K, Tisdale S, Danial N, Benarafa C, Orduna A and Anderson P

  Biochem Biophys Res Commun; 2010 Oct 22. 401 (3):440-446.

• HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species

  Capasso M, Bhamrah M K, Henley T, Boyd R S, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny V V, Morgan D, Gascoyne R D, Vigorito E, DeCoursey T E, MacLennan I C and Dyer M J

  Nat Immunol; 2010 Mar 1. 11 (3):265-272.

Mitochondrial Diseases

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• Microscale oxygraphy reveals OXPHOS impairment in MRC mutant cells

  Invernizzi F, D'Amato I, Jensen P B, Ravaglia S, Zeviani M and Tiranti V

  Mitochondrion. 2012 Jan 28; [Epub ahead of print].

• Partial tandem duplication of mtDNA-tRNA(Phe) impairs mtDNA translation in late-onset mitochondrial myopathy

  Arzuffi P, Lamperti C, Fernandez-Vizarra E, Tonin P, Morandi L and Zeviani M

  Neuromuscul Disord; 2012 Jan 1. 22 (1):50-55.

• Mitochondrial dysfunction in ataxia telangiectasia

  Valentin-Vega Y A, Maclean K H, Tait-Mulder J, Milasta S, Steeves M, Dorsey F C, Cleveland J L, Green D R and Kastan M B

  Blood. 2011 Dec 5; [Epub ahead of print].

• The effects of idebenone on mitochondrial bioenergetics

  Giorgio V, Petronilli V, Ghelli A, Carelli V, Rugolo M, Lenaz G and Bernardi P

  Biochimica et Biophysica Acta (BBA) - Bioenergetics; 2011 Nov 4.

• Human iPSCs Harbor Homoplasmic and Heteroplasmic Mitochondrial DNA Mutations While Maintaining hESC-Like Metabolic Reprogramming

  Prigione A, Lichtner B, Kuhl H, Struys E A, Wamelink M, Lehrach H, Ralser M, Timmermann B and Adjaye J

  Stem Cells; 2011 Sep 1. 29 (9):1338-1348.

• Mutation in the mitochondrial tRNAVal causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes

  Glatz C, D'Aco K, Smith S and Sondheimer N

  Mitochondrion; 2011 Jul 1. 11 (4):615-619.

• Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies

  Ghezzi D, Arzuffi P, Zordan M, Da Re C, Lamperti C, Benna C, D'Adamo P, Diodato D, Costa R, Mariotti C, Uziel G, Smiderle C and Zeviani M

  Nat Genet; 2011 Mar 1. 43 (3):259-263.

• Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts

  Moran M, Rivera H, Sanchez-Arago M, Blazquez A, Merinero B, Ugalde C, Arenas J, Cuezva J M and Martin M A

  Biochim Biophys Acta; 2010 May 1. 1802 (5):443-453.

• Mitochondrial and nuclear genomic responses to loss of LRPPRC expression

  Gohil V M, Nilsson R, Belcher-Timme C A, Luo B, Root D E and Mootha V K

  J Biol Chem; 2010 Apr 30. 285 (18):13742-13747.

• Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD)

  Song Y, Selak M A, Watson C T, Coutts C, Scherer P C, Panzer J A, Gibbs S, Scott M O, Willer G, Gregg R G, Ali D W, Bennett M J and Balice-Gordon R J

  PLoS One; 2009 Dec 17. 4 (12):e8329.

Model Organisms

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• GLUT10 is required for the development of the cardiovascular system and the notochord and connects mitochondrial function to TGFbeta signaling

  Willaert A, Khatri S, Callewaert B L, Coucke P J, Crosby S D, Lee J G, Davis E C, Shiva S, Tsang M, De Paepe A and Urban Z

  Hum Mol Genet. 2011 Nov 24; [Epub ahead of print].

• NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

  Yamamoto H, Williams E G, Mouchiroud L, Canto C, Fan W, Downes M, Heligon C, Barish G D, Desvergne B, Evans R M, Schoonjans K and Auwerx J

  Cell; 2011 Nov 11. 147 (4):827-839.

• Bioenergetic profiling of zebrafish embryonic development

  Stackley K D, Beeson C C, Rahn J J and Chan S S

  PLoS One. 2011 Sep 29; [Epub ahead of print].

• A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3

  Pei W, Kratz L E, Bernardini I, Sood R, Yokogawa T, Dorward H, Ciccone C, Kelley R I, Anikster Y, Burgess H A, Huizing M and Feldman B

  Development; 2010 Aug 1. 137 (15):2587-2596.

• Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD)

  Song Y, Selak M A, Watson C T, Coutts C, Scherer P C, Panzer J A, Gibbs S, Scott M O, Willer G, Gregg R G, Ali D W, Bennett M J and Balice-Gordon R J

  PLoS One; 2009 Dec 17. 4 (12):e8329.

Nephrology

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• Role of mitofusin 2 in the renal stress response

  Gall J M, Wang Z, Liesa M, Molina A, Havasi A, Schwartz J H, Shirihai O, Borkan S C and Bonegio R G

  PLoS One; 2012 Jan 26. 7 (1):e31074.

• Identification of agents that reduce renal hypoxia-reoxygenation injury using cell-based screening: Purine nucleosides are alternative energy sources in LLC-PK1 cells during hypoxia

  Szoleczky P, Modis K, Nagy N, Toth Z D, Dewitt D, Szabo C and Gero D

  Arch Biochem Biophys; 2012 Jan 1. 517 (1):53-70.

• SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells

  Koyama T, Kume S, Koya D, Araki S I, Isshiki K, Chin-Kanasaki M, Sugimoto T, Haneda M, Sugaya T, Kashiwagi A, Maegawa H and Uzu T

  Free Radic Biol Med; 2011 Sep 15. 51 (6):1258-1267.

• The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

  Tong W H, Sourbier C, Kovtunovych G, Jeong S Y, Vira M, Ghosh M, Romero V V, Sougrat R, Vaulont S, Viollet B, Kim Y S, Lee S, Trepel J, Srinivasan R, Bratslavsky G, Yang Y, Linehan W M and Rouault T A

  Cancer Cell; 2011 Sep 13. 20 (3):315-327.

• A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

  Beeson C C, Beeson G C and Schnellmann R G

  Anal Biochem; 2010 Sep 1. 404 (1):75-81.

Neurodegeneration

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• Ethanol withdrawal hastens the aging of cytochrome c oxidase

  Jung M E, Ju X, Metzger D B and Simpkins J W

  Neurobiol Aging; 2012 Mar 1. 33 (3):618.e21-32.

• Selective oestrogen receptor modulators differentially potentiate brain mitochondrial function

  Irwin R W, Yao J, To J, Hamilton R T, Cadenas E and Brinton R D

  J Neuroendocrinol; 2012 Jan 1. 24 (1):236-248.

• Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and mitochondrial deficits

  Sauerbeck A, Hunter R, Bing G and Sullivan P G

  Exp Neurol. 2011 Dec 20; [Epub ahead of print].

• Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: Attenuation by a lipophilic metalloporphyrin

  Liang L P, Waldbaum S, Rowley S, Huang T T, Day B J and Patel M

  Neurobiol Dis. 2011 Dec 16; [Epub ahead of print].

• ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

  Gusdon A M, Zhu J, Van Houten B and Chu C T

  Neurobiol Dis. 2011 Dec 13; [Epub ahead of print].

• Adaptation of microplate-based respirometry for hippocampal slices and analysis of respiratory capacity

  Schuh R A, Clerc P, Hwang H, Mehrabian Z, Bittman K, Chen H and Polster B M

  J Neurosci Res; 2011 Dec 1. 89 (12):1979-1988.

• Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress

  Schneider L, Giordano S, Zelickson B R, Johnson M, Benavides G, Ouyang X, Fineberg N, Darley-Usmar V M and Zhang J

  Free Radical Biology and Medicine; 2011 Dec 1. 51 (11):2007-17.

• Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease

  Dagda R K, Gusdon A M, Pien I, Strack S, Green S, Li C, Van Houten B, Cherra S J, 3rd and Chu C T

  Cell Death Differ; 2011 Dec 1. 18 (12):1914-23.

• DJ-1 knock-down impairs astrocyte mitochondrial function

  Larsen N J, Ambrosi G, Mullett S J, Berman S B and Hinkle D A

  Neuroscience; 2011 Nov 24. (196):251-64.

• DHA protects against zinc mediated alterations in neuronal cellular bioenergetics

  McGee S L, Sadli N, Morrison S, Swinton C and Suphioglu C

  Cell Physiol Biochem; 2011 Aug 26. 28 (1):157-162.

• 2-deoxy-d-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease

  Yao J, Chen S, Mao Z, Cadenas E and Brinton R D

  PLoS One. 2011 Jul 1; [Epub ahead of print].

• Mutation in the mitochondrial tRNAVal causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes

  Glatz C, D'Aco K, Smith S and Sondheimer N

  Mitochondrion; 2011 Jul 1. 11 (4):615-619.

• Mitochondrial aconitase knockdown attenuates paraquat-induced dopaminergic cell death via decreased cellular metabolism and release of iron and H(2) O(2)

  Cantu D, Fulton R E, Drechsel D A and Patel M

  J Neurochem; 2011 Jul 1. 118 (1):79-92.

• High-mobility group box 1 is essential for mitochondrial quality control

  Tang D, Kang R, Livesey K M, Kroemer G, Billiar T R, Van Houten B, Zeh H J, 3rd and Lotze M T

  Cell Metab; 2011 Jun 8. 13 (6):701-711.

• To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease

  Gusdon A M and Chu C T

  Antioxid Redox Signal; 2011 May 15. 14 (10):1979-1987.

• Alternative mitochondrial electron transfer as a novel strategy for neuroprotection

  Wen Y, Li W, Poteet E C, Xie L, Tan C, Yan L J, Ju X, Liu R, Qian H, Marvin M A, Goldberg M S, She H, Mao Z, Simpkins J W and Yang S H

  J Biol Chem; 2011 May 6. 286 (18):16504-16515.

• Ovarian hormone loss induces bioenergetic deficits and mitochondrial beta-amyloid

  Yao J, Irwin R, Chen S, Hamilton R, Cadenas E and Brinton R D

  Neurobiol Aging. 2011 Apr 22; [Epub ahead of print].

• Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice

  Flynn J M, Choi S W, Day N U, Gerencser A A, Hubbard A and Melov S

  Free Radic Biol Med; 2011 Apr 1. 50 (7):866-873.

• Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes

  Choi S W, Gerencser A A, Lee D W, Rajagopalan S, Nicholls D G, Andersen J K and Brand M D

  J Neurosci; 2011 Mar 23. 31 (12):4524-4534.

• Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: Antagonism by progesterone

  Yao J, Chen S, Cadenas E and Brinton R D

  Brain Res; 2011 Mar 16. 1379 (1):40584.

• Analysis of regional brain mitochondrial bioenergetics and susceptibility to mitochondrial inhibition utilizing a microplate based system

  Sauerbeck A, Pandya J, Singh I, Bittman K, Readnower R, Bing G and Sullivan P

  Journal of Neuroscience Methods; 2011 Mar 15. 198 (1):36-43.

• Glutamate Transport Decreases Mitochondrial pH and Modulates Oxidative Metabolism in Astrocytes

  Azarias G, Perreten H, Lengacher S, Poburko D, Demaurex N, Magistretti P J and Chatton J Y

  J Neurosci; 2011 Mar 9. 31 (10):3550-3559.

• Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies

  Ghezzi D, Arzuffi P, Zordan M, Da Re C, Lamperti C, Benna C, D'Adamo P, Diodato D, Costa R, Mariotti C, Uziel G, Smiderle C and Zeviani M

  Nat Genet; 2011 Mar 1. 43 (3):259-263.

• Apolipoprotein e4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

  Chen H K, Ji Z S, Dodson S E, Miranda R D, Rosenblum C I, Reynolds I J, Freedman S B, Weisgraber K H, Huang Y and Mahley R W

  J Biol Chem; 2011 Feb 18. 286 (7):5215-5221.

• Meclizine is neuroprotective in models of Huntington's disease

  Gohil V M, Offner N, Walker J A, Sheth S A, Fossale E, Gusella J F, Macdonald M E, Neri C and Mootha V K

  Hum Mol Genet; 2011 Jan 15. 20 (2):294-300.

• Inducible dopaminergic glutathione depletion in an α-synuclein transgenic mouse model results in age-related olfactory dysfunction

  Kim Y H, Lussier S, Rane A, Choi S W and Andersen J K

  Neuroscience; 2011 Jan 13. 172 (1):379-386.

• Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD Mice

  Varghese M, Zhao W, Wang J, Cheng A, Qian X, Chaudhry A, Ho L and Pasinetti G

  Translational Neuroscience; 2011 Jan 5. 2 (1)

• KB-R7943, an inhibitor of the reverse Na+ /Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I

  Brustovetsky T, Brittain M K, Sheets P L, Cummins T R, Pinelis V and Brustovetsky N

  Br J Pharmacol; 2011 Jan 1. 162 (1):255-270.

• Medroxyprogesterone Acetate Antagonizes Estrogen Up-Regulation of Brain Mitochondrial Function

  Irwin R W, Yao J, Ahmed S S, Hamilton R T, Cadenas E and Brinton R D

  Endocrinology; 2010 Dec 15. 152 (2):556-567.

• Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration

  Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, Salomoni P and Nicotera P

  Hum Mol Genet; 2010 May 1. 19 (9):1669-1677.

• Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

  Gohil V M, Sheth S A, Nilsson R, Wojtovich A P, Lee J H, Perocchi F, Chen W, Clish C B, Ayata C, Brookes P S and Mootha V K

  Nat Biotechnol; 2010 Mar 1. 28 (3):249-255.

• Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies

  Swerdlow R H

  Pharmaceuticals; 2009 Dec 3. 2 (3):150-167.

• Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

  Yao J, Irwin R W, Zhao L, Nilsen J, Hamilton R T and Brinton R D

  Proc Natl Acad Sci U S A; 2009 Aug 25. 106 (34):14670-14675.

• Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

  Choi S W, Gerencser A A and Nicholls D G

  J Neurochem; 2009 May 1. 109 (4):1179-1191.

Obesity, Diabetes & Metabolic Disorders

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• Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1

  Wernstedt Asterholm I, Mundy D I, Weng J, Anderson R G and Scherer P E

  Cell Metab; 2012 Feb 8. 15 (2):171-185.

• Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

  Bordicchia M, Liu D, Amri E Z, Ailhaud G, Dessi-Fulgheri P, Zhang C, Takahashi N, Sarzani R and Collins S

  J Clin Invest. 2012 Feb 6; [Epub ahead of print].

• Dietary obesity-associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system

  Krishnan J, Danzer C, Simka T, Ukropec J, Walter K M, Kumpf S, Mirtschink P, Ukropcova B, Gasperikova D, Pedrazzini T and Krek W

  Genes Dev; 2012 Feb 1. 26 (3):259-270.

• Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol

  Saadeh M, Ferrante T C, Kane A, Shirihai O, Corkey B E and Deeney J T

  PLoS One. 2012 Jan 17; [Epub ahead of print].

• Programming human pluripotent stem cells into white and brown adipocytes

  Ahfeldt T, Schinzel R T, Lee Y K, Hendrickson D, Kaplan A, Lum D H, Camahort R, Xia F, Shay J, Rhee E P, Clish C B, Deo R C, Shen T, Lau F H, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten R E, Rinn J L and Cowan C A

  Nat Cell Biol; 2012 Jan 15. 14 (2):209-19.

• Crucial yet divergent roles of mitochondrial redox state in skeletal muscle vs. brown adipose tissue energetics

  Mailloux R J, Adjeitey C N, Xuan J Y and Harper M E

  FASEB J; 2012 Jan 1. 26 (1):363-75.

• Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes

  Lee J Y, Takahashi N, Yasubuchi M, Kim Y I, Hashizaki H, Kim M J, Sakamoto T, Goto T and Kawada T

  Am J Physiol Cell Physiol; 2012 Jan 1. 302 (2):C463-472.

• Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice

  Ho L, Varghese M, Wang J, Zhao W, Chen F, Knable L A, Ferruzzi M and Pasinetti G M

  Nutr Neurosci; 2012 Jan 1. 15 (1):37-45.

• Human Pompe disease induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification

  Huang H P, Chen P H, Hwu W L, Chuang C Y, Chien Y H, Stone L, Chien C L, Li L T, Chiang S C, Chen H F, Ho H N, Chen C H and Kuo H C

  Hum Mol Genet; 2011 Dec 15. 20 (24):4851-64.

• The nuclear receptor PPARbeta/delta programs muscle glucose metabolism in cooperation with AMPK and MEF2

  Gan Z, Burkart-Hartman E M, Han D H, Finck B, Leone T C, Smith E Y, Ayala J E, Holloszy J and Kelly D P

  Genes Dev; 2011 Dec 15. 25 (24):2619-30.

• Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells

  Aguer C, Gambarotta D, Mailloux R J, Moffat C, Dent R, McPherson R and Harper M E

  PLoS One. 2011 Dec 15; [Epub ahead of print].

• Fatty Acids Suppress Autophagic Turnover in beta-Cells

  Las G, Serada S B, Wikstrom J D, Twig G and Shirihai O S

  J Biol Chem; 2011 Dec 9. 286 (49):42534-42544.

• NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

  Yamamoto H, Williams E G, Mouchiroud L, Canto C, Fan W, Downes M, Heligon C, Barish G D, Desvergne B, Evans R M, Schoonjans K and Auwerx J

  Cell; 2011 Nov 11. 147 (4):827-839.

• High Glucose Induces Mitochondrial Morphology and Metabolic Changes in Retinal Pericytes

  Trudeau K, Molina A J and Roy S

  Invest Ophthalmol Vis Sci; 2011 Nov 7. 52 (12):8657-64.

• Beta-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

  Robson-Doucette C A, Sultan S, Allister E M, Wikstrom J D, Koshkin V, Bhatacharjee A, Prentice K J, Sereda S B, Shirihai O S and Wheeler M B

  Diabetes; 2011 Nov 1. 60 (11):2710-2719.

• The Transcriptional Coactivators, PGC-1? and ?, Cooperate to Maintain Cardiac Mitochondrial Function During the Early Stages of Insulin Resistance

  Mitra R, Nogee D P, Zechner J F, Yea K, Gierasch C M, Kovacs A, Medeiros D M, Kelly D P and Duncan J G

  J Mol Cell Cardiol. 2011 Oct 20; [Epub ahead of print].

• Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

  Tormos K V, Anso E, Hamanaka R B, Eisenbart J, Joseph J, Kalyanaraman B and Chandel N S

  Cell Metab; 2011 Oct 5. 14 (4):537-544.

• Orexin is required for brown adipose tissue development, differentiation, and function

  Sellayah D, Bharaj P and Sikder D

  Cell Metab; 2011 Oct 5. 14 (4):478-490.

• The differential role of hif1beta/arnt and the hypoxic response in adipose function, fibrosis, and inflammation

  Lee K Y, Gesta S, Boucher J, Wang X L and Kahn C R

  Cell Metab; 2011 Oct 5. 14 (4):491-503.

• The PGC-1{alpha}-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes

  Philp A, Belew M Y, Evans A, Pham D, Sivia I, Chen A, Schenk S and Baar K

  Am J Physiol Regul Integr Comp Physiol; 2011 Oct 1. 301 (4):R864-872.

• SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells

  Koyama T, Kume S, Koya D, Araki S I, Isshiki K, Chin-Kanasaki M, Sugimoto T, Haneda M, Sugaya T, Kashiwagi A, Maegawa H and Uzu T

  Free Radic Biol Med; 2011 Sep 15. 51 (6):1258-1267.

• Platelet Mitochondrial Dysfunction is Evident in Type 2 Diabetes in Association with Modifications of Mitochondrial Anti-Oxidant Stress Proteins

  Avila C, Huang R J, Stevens M V, Aponte A M, Tripodi D, Kim K Y and Sack M N

  Exp Clin Endocrinol Diabetes. 2011 Sep 15; [Epub ahead of print].

• A Peroxisome Proliferator-activated Receptor {gamma} (PPAR{gamma})/PPAR{gamma} Coactivator 1{beta} Autoregulatory Loop in Adipocyte Mitochondrial Function

  Deng T, Sieglaff D H, Zhang A, Lyon C J, Ayers S D, Cvoro A, Gupte A A, Xia X, Baxter J D, Webb P and Hsueh W A

  J Biol Chem; 2011 Sep 2. 286 (35):30723-30731.

• Differential regulation of metabolism by nitric oxide and S-nitrosothiols in endothelial cells

  Diers A R, Broniowska K A, Darley-Usmar V M and Hogg N

  Am J Physiol Heart Circ Physiol; 2011 Sep 1. 301 (3):H803-812.

• Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in human adipocytes by activating AMPK

  Souza S C, Chau M D, Yang Q, Gauthier M S, Clairmont K B, Wu Z, Gromada J and Dole W P

  Biochem Biophys Res Commun; 2011 Jul 8. 410 (3):398-403.

• The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells

  Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song W J, Sereda S, Clerc P, Polster B M, Aja S M, Pletnikov M V, Kensler T W, Shirihai O S, Iijima M, Hussain M A and Sesaki H

  Mol Biol Cell; 2011 Jul 1. 22 (13):2235-2245.

• Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy

  Liu N, Bezprozvannaya S, Shelton J M, Frisard M I, Hulver M W, McMillan R P, Wu Y, Voelker K A, Grange R W, Richardson J A, Bassel-Duby R and Olson E N

  The Journal of Clinical Investigation; 2011 Jul 1. 121 (8):3258-3268.

• Activation of peroxisome proliferator-activated receptor-[alpha] (PPAR[alpha]) suppresses postprandial lipidemia through fatty acid oxidation in enterocytes

  Kimura R, Takahashi N, Murota K, Yamada Y, Niiya S, Kanzaki N, Murakami Y, Moriyama T, Goto T and Kawada T

  Biochemical and Biophysical Research Communications; 2011 Jun 24. 410 (1):40549.

• Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3

  Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E

  J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.

• High fat diet induces an initial adaptation of mitochondrial bioenergetics in the kidney despite evident oxidative stress and mitochondrial ROS production

  Ruggiero C, Ehrenshaft M, Cleland E and Stadler K

  Am J Physiol Endocrinol Metab; 2011 Jun 1. 300 (6):1047-1058.

• Reduced cytochrome C is an essential regulator of sustained insulin secretion by pancreatic islets

  Jung S R, Kuok I T, Couron D, Rizzo N, Margineantu D H, Hockenbery D M, Kim F and Sweet I R

  J Biol Chem; 2011 May 20. 286 (20):17422-17434.

• To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease

  Gusdon A M and Chu C T

  Antioxid Redox Signal; 2011 May 15. 14 (10):1979-1987.

• Activation of peroxisome proliferator-activated receptor-alpha enhances fatty acid oxidation in human adipocytes

  Lee J Y, Hashizaki H, Goto T, Sakamoto T, Takahashi N and Kawada T

  Biochem Biophys Res Commun; 2011 Apr 22. 407 (4):818-822.

• PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

  Bai P, Canto C, Oudart H, Brunyanszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper R H, Schoonjans K, Schreiber V, Sauve A A, Menissier-de Murcia J and Auwerx J

  Cell Metab; 2011 Apr 6. 13 (4):461-468.

• PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

  Bai P, Canto C, Brunyanszki A, Huber A, Szanto M, Cen Y, Yamamoto H, Houten S M, Kiss B, Oudart H, Gergely P, Menissier-de Murcia J, Schreiber V, Sauve A A and Auwerx J

  Cell Metab; 2011 Apr 6. 13 (4):450-460.

• Ncb5or deficiency increases fatty acid catabolism and oxidative stress

  Xu M, Wang W, Frontera J R, Neely M C, Lu J J, Aires D, Hsu F F, Turk J, Swerdlow R H, Carlson S E and Zhu H

  J Biol Chem; 2011 Apr 1. 286 (13):11141-11154.

• Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal beta-cell lines

  Spegel P, Malmgren S, Sharoyko V V, Newsholme P, Koeck T and Mulder H

  Biochem J; 2011 Apr 1. 435 (1):277-284.

• Inactivation of the mitochondrial carrier SLC25A25 (ATP-MG2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice

  Anunciado-Koza R P, Zhang J, Ukropec J, Bajpeyi S, Koza R A, Rogers R C, Cefalu W T, Mynatt R L and Kozak L P

  J Biol Chem; 2011 Apr 1. 286 (13):11659-11671.

• Dietary fat sensing via fatty acid oxidation in enterocytes: possible role in the control of eating

  Langhans W, Leitner C and Arnold M

  Am J Physiol Regul Integr Comp Physiol; 2011 Mar 1. 300 (3):R554-565.

• Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species

  Affourtit C, Jastroch M and Brand M D

  Free Radic Biol Med; 2011 Mar 1. 50 (5):609-616.

• Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance

  Fang S, Suh J M, Atkins A R, Hong S H, Leblanc M, Nofsinger R R, Yu R T, Downes M and Evans R M

  Proc Natl Acad Sci U S A; 2011 Feb 22. 108 (8):3412-3417.

• Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration

  Gesta S, Bezy O, Mori M A, Macotela Y, Lee K Y and Kahn C R

  Proc Natl Acad Sci U S A; 2011 Feb 15. 108 (7):2771-2776.

• Telomere dysfunction induces metabolic and mitochondrial compromise

  Sahin E, Colla S, Liesa M, Moslehi J, Muller F L, Guo M, Cooper M, Kotton D, Fabian A J, Walkey C, Maser R S, Tonon G, Foerster F, Xiong R, Wang Y A, Shukla S A, Jaskelioff M, Martin E S, Heffernan T P, Protopopov A, Ivanova E, Mahoney J E, Kost-Alimova M, Perry S R, Bronson R, Liao R, Mulligan R, Shirihai O S, Chin L and DePinho R A

  Nature; 2011 Feb 9. 470 (7334):359-365.

• The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

  da-Silva W S, Ribich S, Drigo R A, Castillo M, Patti M E and Bianco A C

  FEBS Lett; 2011 Feb 4. 585 (3):539-544.

• Wnt signaling regulates hepatic metabolism

  Liu H, Fergusson M M, Wu J J, Rovira, II, Liu J, Gavrilova O, Lu T, Bao J, Han D, Sack M N and Finkel T

  Sci Signal; 2011 Feb 1. 4 (158):ra6.

• The adipocyte-expressed forkhead transcription factor foxc2 regulates metabolism through altered mitochondrial function

  Lidell M E, Seifert E L, Westergren R, Heglind M, Gowing A, Sukonina V, Arani Z, Itkonen P, Wallin S, Westberg F, Fernandez-Rodriguez J, Laakso M, Nilsson T, Peng X R, Harper M E and Enerback S

  Diabetes; 2011 Feb 1. 60 (2):427-435.

• A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

  Koeck T, Olsson A H, Nitert M D, Sharoyko V V, Ladenvall C, Kotova O, Reiling E, Ronn T, Parikh H, Taneera J, Eriksson J G, Metodiev M D, Larsson N G, Balhuizen A, Luthman H, Stancakova A, Kuusisto J, Laakso M, Poulsen P, Vaag A, Groop L, Lyssenko V, Mulder H and Ling C

  Cell Metab; 2011 Jan 5. 13 (1):80-91.

• Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

  Schulz T J, Huang T L, Tran T T, Zhang H, Townsend K L, Shadrach J L, Cerletti M, McDougall L E, Giorgadze N, Tchkonia T, Schrier D, Falb D, Kirkland J L, Wagers A J and Tseng Y H

  Proc Natl Acad Sci U S A; 2011 Jan 4. 108 (1):143-148.

• Mechanisms of metformin action on glucose transport and metabolism in human adipocytes

  Grisouard J, Timper K, Radimerski T M, Frey D M, Peterli R, Kola B, Korbonits M, Herrmann P, Krahenbuhl S, Zulewski H, Keller U, Muller B and Christ-Crain M

  Biochem Pharmacol; 2010 Dec 1. 80 (11):1736-1745.

• 9-oxo-10(E),12(E)-octadecadienoic acid derived from tomato is a potent PPAR α agonist to decrease triglyceride accumulation in mouse primary hepatocytes

  Kim Y I, Hirai S, Takahashi H, Goto T, Ohyane C, Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N and Kawada T

  Mol Nutr Food Res. 2010 Nov 18; [Epub ahead of print].

• Heart-type fatty acid binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance

  Vergnes L, Chin R, Young S G and Reue K

  J Biol Chem; 2010 Nov 1. 286 (1):380-390.

• Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

  Akhmedov D, Braun M, Mataki C, Park K S, Pozzan T, Schoonjans K, Rorsman P, Wollheim C B and Wiederkehr A

  FASEB J; 2010 Nov 1. 24 (11):4613-4626.

• SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells

  Nasrin N, Wu X, Fortier E, Feng Y, Bare O C, Chen S, Ren X, Wu Z, Streeper R S and Bordone L

  J Biol Chem; 2010 Oct 15. 285 (42):31995-32002.

• Acute stimulation of white adipocyte respiration by PKA-induced lipolysis

  Yehuda-Shnaidman E, Buehrer B, Pi J, Kumar N and Collins S

  Diabetes; 2010 Oct 1. 59 (10):2474-2483.

• Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis

  Hall J A, Ribich S, Christoffolete M A, Simovic G, Correa-Medina M, Patti M E and Bianco A C

  Endocrinology; 2010 Sep 1. 151 (9):4573-4582.

• A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

  Beeson C C, Beeson G C and Schnellmann R G

  Anal Biochem; 2010 Sep 1. 404 (1):75-81.

• Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity

  Li J, Romestaing C, Han X, Li Y, Hao X, Wu Y, Sun C, Liu X, Jefferson L S, Xiong J, Lanoue K F, Chang Z, Lynch C J, Wang H and Shi Y

  Cell Metab; 2010 Aug 4. 12 (2):154-165.

• Respiration in adipocytes is inhibited by reactive oxygen species

  Wang T, Si Y, Shirihai O S, Si H, Schultz V, Corkey R F, Hu L, Deeney J T, Guo W and Corkey B E

  Obesity (Silver Spring); 2010 Aug 1. 18 (8):1493-1502.

• Pyruvate suppresses PGC1α expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes

  Philp A, Perez-Schindler J, Green C, Hamilton D L and Baar K

  Am J Physiol Cell Physiol; 2010 Aug 1. 299 (2):C240-250.

• A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3

  Pei W, Kratz L E, Bernardini I, Sood R, Yokogawa T, Dorward H, Ciccone C, Kelley R I, Anikster Y, Burgess H A, Huizing M and Feldman B

  Development; 2010 Aug 1. 137 (15):2587-2596.

• Wnt signaling regulates mitochondrial physiology and insulin sensitivity

  Yoon J C, Ng A, Kim B H, Bianco A, Xavier R J and Elledge S J

  Genes Dev; 2010 Jul 15. 24 (14):1507-1518.

• Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1α pathway

  Chau M D, Gao J, Yang Q, Wu Z and Gromada J

  Proc Natl Acad Sci U S A; 2010 Jul 13. 107 (28):12553-12558.

• Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis

  Ellis J M, Li L O, Wu P C, Koves T R, Ilkayeva O, Stevens R D, Watkins S M, Muoio D M and Coleman R A

  Cell Metab; 2010 Jul 4. 12 (1):53-64.

• High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy

  Trudeau K, Molina A J, Guo W and Roy S

  Am J Pathol; 2010 Jul 1. 177 (1):447-455.

• Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells, a novel role for glucose-6-phosphate dehydrogenase

  Mailloux R J and Harper M E

  FASEB J; 2010 Jul 1. 24 (7):2495-2506.

• Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells

  Krus U, Kotova O, Spegel P, Hallgard E, Sharoyko V V, Vedin A, Moritz T, Sugden M C, Koeck T and Mulder H

  Biochem J; 2010 Jul 1. 429 (1):205-213.

• Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL

  Civitarese A E, MacLean P S, Carling S, Kerr-Bayles L, McMillan R P, Pierce A, Becker T C, Moro C, Finlayson J, Lefort N, Newgard C B, Mandarino L, Cefalu W, Walder K, Collier G R, Hulver M W, Smith S R and Ravussin E

  Cell Metab; 2010 May 5. 11 (5):412-426.

• Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage

  Chakrabarti P, English T, Shi J, Smas C M and Kandror K V

  Diabetes; 2010 Apr 1. 59 (4):775-781.

• The homeobox protein Prox1 is a negative modulator of ERR{α}/PGC-1{α} bioenergetic functions

  Charest-Marcotte A, Dufour C R, Wilson B J, Tremblay A M, Eichner L J, Arlow D H, Mootha V K and Giguere V

  Genes Dev; 2010 Mar 15. 24 (6):537-542.

• Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

  Canto C, Jiang L Q, Deshmukh A S, Mataki C, Coste A, Lagouge M, Zierath J R and Auwerx J

  Cell Metab; 2010 Mar 3. 11 (3):213-219.

• Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

  Gohil V M, Sheth S A, Nilsson R, Wojtovich A P, Lee J H, Perocchi F, Chen W, Clish C B, Ayata C, Brookes P S and Mootha V K

  Nat Biotechnol; 2010 Mar 1. 28 (3):249-255.

• A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells

  Shaham O, Slate N G, Goldberger O, Xu Q, Ramanathan A, Souza A L, Clish C B, Sims K B and Mootha V K

  Proc Natl Acad Sci U S A; 2010 Jan 26. 107 (4):1571-1575.

• The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1α

  Zhong L, D'Urso A, Toiber D, Sebastian C, Henry R E, Vadysirisack D D, Guimaraes A, Marinelli B, Wikstrom J D, Nir T, Clish C B, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai O S, Ellisen L W, Espinosa J M and Mostoslavsky R

  Cell; 2010 Jan 22. 140 (2):280-293.

• Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77

  Chao L C, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva O R, Ding S Y, Reue K, Watt M J, Newgard C B, Pilch P F, Hevener A L and Tontonoz P

  Diabetes; 2009 Dec 1. 58 (12):2788-2796.

• Insulin signaling regulates mitochondrial function in pancreatic beta-cells

  Liu S, Okada T, Assmann A, Soto J, Liew C W, Bugger H, Shirihai O S, Abel E D and Kulkarni R N

  PLoS One; 2009 Nov 24. 4 (11):e7983.

• Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion

  Malmgren S, Nicholls D G, Taneera J, Bacos K, Koeck T, Tamaddon A, Wibom R, Groop L, Ling C, Mulder H and Sharoyko V V

  J Biol Chem; 2009 Nov 20. 284 (47):32395-32404.

• Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue

  Kang H W, Ribich S, Kim B W, Hagen S J, Bianco A C and Cohen D E

  J Lipid Res; 2009 Nov 1. 50 (11):2212-2221.

• KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity

  Costanzo-Garvey D L, Pfluger P T, Dougherty M K, Stock J L, Boehm M, Chaika O, Fernandez M R, Fisher K, Kortum R L, Hong E G, Jun J Y, Ko H J, Schreiner A, Volle D J, Treece T, Swift A L, Winer M, Chen D, Wu M, Leon L R, Shaw A S, McNeish J, Kim J K, Morrison D K, Tschop M H and Lewis R E

  Cell Metab; 2009 Nov 1. 10 (5):366-378.

• C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists

  Vernochet C, Peres S B, Davis K E, McDonald M E, Qiang L, Wang H, Scherer P E and Farmer S R

  Mol Cell Biol; 2009 Sep 1. 29 (17):4714-4728.

• TGR5-mediated bile acid sensing controls glucose homeostasis

  Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J and Schoonjans K

  Cell Metab; 2009 Sep 1. 10 (3):167-177.

• AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

  Canto C, Gerhart-Hines Z, Feige J N, Lagouge M, Noriega L, Milne J C, Elliott P J, Puigserver P and Auwerx J

  Nature; 2009 Apr 23. 458 (7241):1056-1060.

• Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

  Feige J N, Lagouge M, Canto C, Strehle A, Houten S M, Milne J C, Lambert P D, Mataki C, Elliott P J and Auwerx J

  Cell Metab; 2008 Nov 1. 8 (5):347-358.

• Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

  Twig G, Elorza A, Molina A J, Mohamed H, Wikstrom J D, Walzer G, Stiles L, Haigh S E, Katz S, Las G, Alroy J, Wu M, Py B F, Yuan J, Deeney J T, Corkey B E and Shirihai O S

  EMBO J; 2008 Jan 23. 27 (2):433-446.

• Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation

  Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva W S, Espinoza D, Faucette R, Barry K, Bianco A C and Patti M E

  J Biol Chem; 2007 May 25. 282 (21):15439-15450.

• The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation

  da-Silva W S, Harney J W, Kim B W, Li J, Bianco S D, Crescenzi A, Christoffolete M A, Huang S A and Bianco A C

  Diabetes; 2007 Mar 1. 56 (3):767-776.

• Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

  Watanabe M, Houten S M, Mataki C, Christoffolete M A, Kim B W, Sato H, Messaddeq N, Harney J W, Ezaki O, Kodama T, Schoonjans K, Bianco A C and Auwerx J

  Nature; 2006 Jan 26. 439 (7075):484-489.

Screening

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• 9-oxo-10(E),12(E)-octadecadienoic acid derived from tomato is a potent PPAR α agonist to decrease triglyceride accumulation in mouse primary hepatocytes

  Kim Y I, Hirai S, Takahashi H, Goto T, Ohyane C, Tsugane T, Konishi C, Fujii T, Inai S, Iijima Y, Aoki K, Shibata D, Takahashi N and Kawada T

  Mol Nutr Food Res. 2010 Nov 18; [Epub ahead of print].

• A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

  Beeson C C, Beeson G C and Schnellmann R G

  Anal Biochem; 2010 Sep 1. 404 (1):75-81.

• Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

  Gohil V M, Sheth S A, Nilsson R, Wojtovich A P, Lee J H, Perocchi F, Chen W, Clish C B, Ayata C, Brookes P S and Mootha V K

  Nat Biotechnol; 2010 Mar 1. 28 (3):249-255.

• A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis

  Baughman J M, Nilsson R, Gohil V M, Arlow D H, Gauhar Z and Mootha V K

  PLoS Genet; 2009 Aug 1. 5 (8):e1000590.

• Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

  Dykens J A, Jamieson J, Marroquin L, Nadanaciva S, Billis P A and Will Y

  Toxicol Appl Pharmacol; 2008 Dec 1. 233 (2):203-210.

• In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone

  Dykens J A, Jamieson J D, Marroquin L D, Nadanaciva S, Xu J J, Dunn M C, Smith A R and Will Y

  Toxicol Sci; 2008 Jun 1. 103 (2):335-345.

• Advances in measuring cellular bioenergetics using extracellular flux

  Ferrick D A, Neilson A and Beeson C

  Drug Discov Today; 2008 Mar 1. 13 (40669):268-274.

Stem Cell Biology

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• Programming human pluripotent stem cells into white and brown adipocytes

  Ahfeldt T, Schinzel R T, Lee Y K, Hendrickson D, Kaplan A, Lum D H, Camahort R, Xia F, Shay J, Rhee E P, Clish C B, Deo R C, Shen T, Lau F H, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten R E, Rinn J L and Cowan C A

  Nat Cell Biol; 2012 Jan 15. 14 (2):209-19.

• The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

  Panopoulos A D, Yanes O, Ruiz S, Kida Y S, Diep D, Tautenhahn R, Herrerias A, Batchelder E M, Plongthongkum N, Lutz M, Berggren W T, Zhang K, Evans R M, Siuzdak G and Belmonte J C

  Cell Res; 2012 Jan 1. 22 (1):168-77.

• Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes

  Lee J Y, Takahashi N, Yasubuchi M, Kim Y I, Hashizaki H, Kim M J, Sakamoto T, Goto T and Kawada T

  Am J Physiol Cell Physiol; 2012 Jan 1. 302 (2):C463-472.

• Human Pompe disease induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification

  Huang H P, Chen P H, Hwu W L, Chuang C Y, Chien Y H, Stone L, Chien C L, Li L T, Chiang S C, Chen H F, Ho H N, Chen C H and Kuo H C

  Hum Mol Genet; 2011 Dec 15. 20 (24):4851-64.

• Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis

  Estrada J C, Albo C, Benguria A, Dopazo A, Lopez-Romero P, Carrera-Quintanar L, Roche E, Clemente E P, Enriquez J A, Bernad A and Samper E

  Cell Death Differ. 2011 Dec 2; [Epub ahead of print].

• A critical role of mitochondrial phosphatase ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells

  Shen J, Liu X, Yu W M, Liu J, Groot Nibbelink M, Guo C, Finkel T and Qu C K

  Mol Cell Biol; 2011 Dec 1. 31 (24):4902-4916.

• Mitochondrial development of the in vitro hepatic organogenesis model with simultaneous cardiac mesoderm differentiation from murine induced pluripotent stem cells

  Tamai M, Yamashita A and Tagawa Y I

  J Biosci Bioeng; 2011 Nov 1. 112 (5):495-500.

• Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

  Tormos K V, Anso E, Hamanaka R B, Eisenbart J, Joseph J, Kalyanaraman B and Chandel N S

  Cell Metab; 2011 Oct 5. 14 (4):537-544.

• Metabolic state of glioma stem cells and nontumorigenic cells

  Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel P S and Pajonk F

  Proc Natl Acad Sci U S A; 2011 Sep 20. 108 (38):16062-16067.

• Human iPSCs Harbor Homoplasmic and Heteroplasmic Mitochondrial DNA Mutations While Maintaining hESC-Like Metabolic Reprogramming

  Prigione A, Lichtner B, Kuhl H, Struys E A, Wamelink M, Lehrach H, Ralser M, Timmermann B and Adjaye J

  Stem Cells; 2011 Sep 1. 29 (9):1338-1348.

• Mitochondria determine the differentiation potential of cardiac mesoangioblasts

  San Martin N, Cervera A M, Cordova C, Covarello D, McCreath K J and Galvez B G

  Stem Cells; 2011 Jul 1. 29 (7):1064-1074.

• Energy metabolism in human pluripotent stem cells and their differentiated counterparts

  Varum S, Rodrigues A S, Moura M B, Momcilovic O, Easley C A t, Ramalho-Santos J, Van Houten B and Schatten G

  PLoS One. 2011 Jun 17; [Epub ahead of print].

• A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells

  Birket M J, Orr A L, Gerencser A A, Madden D T, Vitelli C, Swistowski A, Brand M D and Zeng X

  J Cell Sci; 2011 Feb 1. 124 (Pt 3):348-358.

Toxicology & Hepatobiology

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• The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery

  Thomas C E and Will Y

  Expert Opinion on Drug Discovery; 2012 Feb 1. 7 (2):109-122.

• Gene-dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia susceptible muscle

  Barrientos G C, Feng W, Truong K, Matthaei K I, Yang T, Allen P D, Lopez J R and Pessah I N

  J Biol Chem; 2012 Jan 20. 287 (4):2863-76.

• Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: The protective role of autophagy

  Higdon A N, Benavides G A, Chacko B K, Ouyang X, Johnson M S, Landar A, Zhang J and Darley-Usmar V M

  Am J Physiol Heart Circ Physiol. 2012 Jan 13; [Epub ahead of print].

• Ethanol Suppresses Ureagenesis in Rat Hepatocytes: Role of Acetaldehyde

  Holmuhamedov E L, Czerny C, Beeson C C and Lemasters J J

  J Biol Chem. 2012 Jan 6; [Epub ahead of print].

• Molecular Analysis of Mitochondrial Compromise in Rodent Cardiomyocytes Exposed Long Term to Nucleoside Reverse Transcriptase Inhibitors (NRTIs)

  Liu Y, Nguyen P, Baris T Z and Poirier M C

  Cardiovasc Toxicol. 2011 Dec 15; [Epub ahead of print].

• Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes

  Zelickson B R, Benavides G A, Johnson M S, Chacko B K, Venkatraman A, Landar A, Betancourt A M, Bailey S M and Darley-Usmar V M

  Biochim Biophys Acta; 2011 Dec 1. 1807 (12):1573-82.

• Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt

  Mullen P J, Zahno A, Lindinger P, Maseneni S, Felser A, Krahenbuhl S and Brecht K

  Biochim Biophys Acta; 2011 Dec 1. 1813 (12):2079-87.

• Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: implications for liver regeneration

  Fernandez-Rojo M A, Restall C, Ferguson C, Martel N, Martin S, Bosch M, Kassan A, Leong G M, Martin S D, McGee S L, Muscat G E, Anderson R L, Enrich C, Pol A and Parton R G

  Hepatology. 2011 Nov 22; [Epub ahead of print].

• Mitochondrial development of the in vitro hepatic organogenesis model with simultaneous cardiac mesoderm differentiation from murine induced pluripotent stem cells

  Tamai M, Yamashita A and Tagawa Y I

  J Biosci Bioeng; 2011 Nov 1. 112 (5):495-500.

• Metabolic profiles show specific mitochondrial toxicities in vitro in myotube cells

  Xu Q, Vu H, Liu L, Wang T C and Schaefer W H

  J Biomol NMR; 2011 Apr 1. 49 (4-Mar):207-219.

• The role of CYP3A4 in amiodarone-associated toxicity on HepG2 cells

  Zahno A, Brecht K, Morand R, Maseneni S, Torok M, Lindinger P W and Krahenbuhl S

  Biochem Pharmacol; 2011 Feb 1. 81 (3):432-441.

• Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

  Dykens J A, Jamieson J, Marroquin L, Nadanaciva S, Billis P A and Will Y

  Toxicol Appl Pharmacol; 2008 Dec 1. 233 (2):203-210.

• In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone

  Dykens J A, Jamieson J D, Marroquin L D, Nadanaciva S, Xu J J, Dunn M C, Smith A R and Will Y

  Toxicol Sci; 2008 Jun 1. 103 (2):335-345.

• Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring the Extracellular Flux of Oxygen and Protons

  Ferrick D, Wu M, Swift A L and Neilson A

  Drug-Induced Mitochondrial Dysfunction; 2008 Jan 22. :Ch 14.

Translational Medicine

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• Microscale oxygraphy reveals OXPHOS impairment in MRC mutant cells

  Invernizzi F, D'Amato I, Jensen P B, Ravaglia S, Zeviani M and Tiranti V

  Mitochondrion. 2012 Jan 28; [Epub ahead of print].

• Identification and analysis of the active phytochemicals from the anti-cancer botanical extract bezielle

  Chen V, Staub R E, Baggett S, Chimmani R, Tagliaferri M, Cohen I and Shtivelman E

  PLoS One. 2012 Jan 17; [Epub ahead of print].

• Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells

  Aguer C, Gambarotta D, Mailloux R J, Moffat C, Dent R, McPherson R and Harper M E

  PLoS One. 2011 Dec 15; [Epub ahead of print].

• The effects of idebenone on mitochondrial bioenergetics

  Giorgio V, Petronilli V, Ghelli A, Carelli V, Rugolo M, Lenaz G and Bernardi P

  Biochimica et Biophysica Acta (BBA) - Bioenergetics; 2011 Nov 4.

• The Transcriptional Coactivators, PGC-1? and ?, Cooperate to Maintain Cardiac Mitochondrial Function During the Early Stages of Insulin Resistance

  Mitra R, Nogee D P, Zechner J F, Yea K, Gierasch C M, Kovacs A, Medeiros D M, Kelly D P and Duncan J G

  J Mol Cell Cardiol. 2011 Oct 20; [Epub ahead of print].

• Platelet Mitochondrial Dysfunction is Evident in Type 2 Diabetes in Association with Modifications of Mitochondrial Anti-Oxidant Stress Proteins

  Avila C, Huang R J, Stevens M V, Aponte A M, Tripodi D, Kim K Y and Sack M N

  Exp Clin Endocrinol Diabetes. 2011 Sep 15; [Epub ahead of print].

• Human iPSCs Harbor Homoplasmic and Heteroplasmic Mitochondrial DNA Mutations While Maintaining hESC-Like Metabolic Reprogramming

  Prigione A, Lichtner B, Kuhl H, Struys E A, Wamelink M, Lehrach H, Ralser M, Timmermann B and Adjaye J

  Stem Cells; 2011 Sep 1. 29 (9):1338-1348.

• SRT1720 improves survival and healthspan of obese mice

  Minor R K, Baur J A, Gomes A P, Ward T M, Csiszar A, Mercken E M, Abdelmohsen K, Shin Y-K, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta P M, Martin-Montalvo A, Hubbard B P, Zhang Y, Lehrmann E, White A A, Price N L, Swindell W R, Pearson K J, Becker K G, Bohr V A, Gorospe M, Egan J M, Talan M I, Auwerx J, Westphal C H, Ellis J L, Ungvari Z, Vlasuk G P, Elliott P J, Sinclair D A and de Cabo R

  Sci. Rep.; 2011 Aug 18. 1 (2011)

• Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function

  Suzuki K, Olah G, Modis K, Coletta C, Kulp G, Gero D, Szoleczky P, Chang T, Zhou Z, Wu L, Wang R, Papapetropoulos A and Szabo C

  Proc Natl Acad Sci U S A; 2011 Aug 16. 108 (33):13829-13834.

• Withaferin a-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species

  Hahm E R, Moura M B, Kelley E E, Van Houten B, Shiva S and Singh S V

  PLoS One. 2011 Aug 10; [Epub ahead of print].

• Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

  Chan D A, Sutphin P D, Nguyen P, Turcotte S, Lai E W, Banh A, Reynolds G E, Chi J T, Wu J, Solow-Cordero D E, Bonnet M, Flanagan J U, Bouley D M, Graves E E, Denny W A, Hay M P and Giaccia A J

  Sci Transl Med; 2011 Aug 3. 3 (94):94ra70.

• 2-deoxy-d-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease

  Yao J, Chen S, Mao Z, Cadenas E and Brinton R D

  PLoS One. 2011 Jul 1; [Epub ahead of print].

• Mutation in the mitochondrial tRNAVal causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes

  Glatz C, D'Aco K, Smith S and Sondheimer N

  Mitochondrion; 2011 Jul 1. 11 (4):615-619.

• Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC

  Yamasaki T, Tran T A, Oz O K, Raj G V, Schwarz R E, Deberardinis R J, Zhang X and Brugarolas J

  Nat Rev Urol; 2011 Mar 1. 8 (3):165-171.

• Apolipoprotein e4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

  Chen H K, Ji Z S, Dodson S E, Miranda R D, Rosenblum C I, Reynolds I J, Freedman S B, Weisgraber K H, Huang Y and Mahley R W

  J Biol Chem; 2011 Feb 18. 286 (7):5215-5221.

• Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain

  Oliva C R, Nozell S E, Diers A, McClugage S G, 3rd, Sarkaria J N, Markert J M, Darley-Usmar V M, Bailey S M, Gillespie G Y, Landar A and Griguer C E

  J Biol Chem; 2010 Dec 17. 285 (51):39759-39767.

• Medroxyprogesterone Acetate Antagonizes Estrogen Up-Regulation of Brain Mitochondrial Function

  Irwin R W, Yao J, Ahmed S S, Hamilton R T, Cadenas E and Brinton R D

  Endocrinology; 2010 Dec 15. 152 (2):556-567.

• Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL

  Civitarese A E, MacLean P S, Carling S, Kerr-Bayles L, McMillan R P, Pierce A, Becker T C, Moro C, Finlayson J, Lefort N, Newgard C B, Mandarino L, Cefalu W, Walder K, Collier G R, Hulver M W, Smith S R and Ravussin E

  Cell Metab; 2010 May 5. 11 (5):412-426.

• Mechanisms underlying metabolic and neural defects in zebrafish and human multiple acyl-CoA dehydrogenase deficiency (MADD)

  Song Y, Selak M A, Watson C T, Coutts C, Scherer P C, Panzer J A, Gibbs S, Scott M O, Willer G, Gregg R G, Ali D W, Bennett M J and Balice-Gordon R J

  PLoS One; 2009 Dec 17. 4 (12):e8329.

Technology

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• Adaptation of microplate-based respirometry for hippocampal slices and analysis of respiratory capacity

  Schuh R A, Clerc P, Hwang H, Mehrabian Z, Bittman K, Chen H and Polster B M

  J Neurosci Res; 2011 Dec 1. 89 (12):1979-1988.

• Assessing bioenergetic function in response to oxidative stress by metabolic profiling

  Dranka B P, Benavides G A, Diers A R, Giordano S, Zelickson B R, Reily C, Zou L, Chatham J C, Hill B G, Zhang J, Landar A and Darley-Usmar V M

  Free Radic Biol Med; 2011 Nov 1. 51 (9):1621-1635.

• High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria

  Rogers G, Brand M D, Petrosyan S, Ashok D, Elorza A, Ferrick D and Murphy A N

  PLoS One. 2011 Jul 25; [Epub ahead of print].

• Assessing mitochondrial dysfunction in cells

  Brand M D and Nicholls D

  Biochem J; 2011 Mar 29. 435 (1):297-312.

• Analysis of regional brain mitochondrial bioenergetics and susceptibility to mitochondrial inhibition utilizing a microplate based system

  Sauerbeck A, Pandya J, Singh I, Bittman K, Readnower R, Bing G and Sullivan P

  Journal of Neuroscience Methods; 2011 Mar 15. 198 (1):36-43.

• Assays Based on Integrated Cell System Properties

  Wu G

  Assay Development: Fundamentals and Practices. 2010 Jun 16; [Epub ahead of print].

• A microfabricated reservoir-type oxygen sensor for measuring the real-time cellular oxygen consumption rate at various conditions

  Park J, Pak Y K and Pak J J

  Sensors and Actuators B: Chemical; 2010 May 18. 147 (1):263-269.

• Quantitative microplate-based respirometry with correction for oxygen diffusion

  Gerencser A A, Neilson A, Choi S W, Edman U, Yadava N, Oh R J, Ferrick D A, Nicholls D G and Brand M D

  Anal Chem; 2009 Aug 15. 81 (16):6868-6878.

• Advances in measuring cellular bioenergetics using extracellular flux

  Ferrick D A, Neilson A and Beeson C

  Drug Discov Today; 2008 Mar 1. 13 (40669):268-274.

• Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

  Wu M, Neilson A, Swift A L, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S and Ferrick D A

  Am J Physiol Cell Physiol; 2007 Jan 1. 292 (1):C125-136.

Review Articles

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• The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery

  Thomas C E and Will Y

  Expert Opinion on Drug Discovery; 2012 Feb 1. 7 (2):109-122.

• Mitochondria: isolation, structure and function

  Picard M, Taivassalo T, Gouspillou G and Hepple R T

  J Physiol; 2011 Sep 15. 589 (Pt 18):4413-4421.

• Uncoupling proteins and the control of mitochondrial reactive oxygen species production

  Mailloux R J and Harper M E

  Free Radic Biol Med; 2011 Sep 15. 51 (6):1106-1115.

• To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease

  Gusdon A M and Chu C T

  Antioxid Redox Signal; 2011 May 15. 14 (10):1979-1987.

• Assessing mitochondrial dysfunction in cells

  Brand M D and Nicholls D

  Biochem J; 2011 Mar 29. 435 (1):297-312.

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