Applications in Stem Cell Biology

App Notes & Tech Briefs

• Bioenergetic analysis of suspension cells: hematopoietic stem cells and lymphocytes

  A real time assay that quantifies the ATP and biosynthetic demands of immune cell proliferation, differentiation and effector function.

  Normal suspension cells, such as hematopoietic cells and lymphocytes are responsible for supplying oxygen to the body and protecting the host. Cellular metabolism is markedly dynamic in immune responses during proliferation and immune effector functions...

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Publications

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• A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells

  Birket M J, Orr A L, Gerencser A A, Madden D T, Vitelli C, Swistowski A, Brand M D and Zeng X

  J Cell Sci; 2011 Feb 1. 124 (Pt 3):348-358.

• Energy metabolism in human pluripotent stem cells and their differentiated counterparts

  Varum S, Rodrigues A S, Moura M B, Momcilovic O, Easley C A t, Ramalho-Santos J, Van Houten B and Schatten G

  PLoS One. 2011 Jun 17; [Epub ahead of print].

• Mitochondria determine the differentiation potential of cardiac mesoangioblasts

  San Martin N, Cervera A M, Cordova C, Covarello D, McCreath K J and Galvez B G

  Stem Cells; 2011 Jul 1. 29 (7):1064-1074.

• Human iPSCs Harbor Homoplasmic and Heteroplasmic Mitochondrial DNA Mutations While Maintaining hESC-Like Metabolic Reprogramming

  Prigione A, Lichtner B, Kuhl H, Struys E A, Wamelink M, Lehrach H, Ralser M, Timmermann B and Adjaye J

  Stem Cells; 2011 Sep 1. 29 (9):1338-1348.

• Metabolic state of glioma stem cells and nontumorigenic cells

  Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel P S and Pajonk F

  Proc Natl Acad Sci U S A; 2011 Sep 20. 108 (38):16062-16067.

• Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

  Tormos K V, Anso E, Hamanaka R B, Eisenbart J, Joseph J, Kalyanaraman B and Chandel N S

  Cell Metab; 2011 Oct 5. 14 (4):537-544.

• Mitochondrial development of the in vitro hepatic organogenesis model with simultaneous cardiac mesoderm differentiation from murine induced pluripotent stem cells

  Tamai M, Yamashita A and Tagawa Y I

  J Biosci Bioeng; 2011 Nov 1. 112 (5):495-500.

• A critical role of mitochondrial phosphatase ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells

  Shen J, Liu X, Yu W M, Liu J, Groot Nibbelink M, Guo C, Finkel T and Qu C K

  Mol Cell Biol; 2011 Dec 1. 31 (24):4902-4916.

• Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis

  Estrada J C, Albo C, Benguria A, Dopazo A, Lopez-Romero P, Carrera-Quintanar L, Roche E, Clemente E P, Enriquez J A, Bernad A and Samper E

  Cell Death Differ. 2011 Dec 2; [Epub ahead of print].

• Human Pompe disease induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification

  Huang H P, Chen P H, Hwu W L, Chuang C Y, Chien Y H, Stone L, Chien C L, Li L T, Chiang S C, Chen H F, Ho H N, Chen C H and Kuo H C

  Hum Mol Genet; 2011 Dec 15. 20 (24):4851-64.

• Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes

  Lee J Y, Takahashi N, Yasubuchi M, Kim Y I, Hashizaki H, Kim M J, Sakamoto T, Goto T and Kawada T

  Am J Physiol Cell Physiol; 2012 Jan 1. 302 (2):C463-472.

• The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

  Panopoulos A D, Yanes O, Ruiz S, Kida Y S, Diep D, Tautenhahn R, Herrerias A, Batchelder E M, Plongthongkum N, Lutz M, Berggren W T, Zhang K, Evans R M, Siuzdak G and Belmonte J C

  Cell Res; 2012 Jan 1. 22 (1):168-77.

• Programming human pluripotent stem cells into white and brown adipocytes

  Ahfeldt T, Schinzel R T, Lee Y K, Hendrickson D, Kaplan A, Lum D H, Camahort R, Xia F, Shay J, Rhee E P, Clish C B, Deo R C, Shen T, Lau F H, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten R E, Rinn J L and Cowan C A

  Nat Cell Biol; 2012 Jan 15. 14 (2):209-19.

Technical Posters

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• Assessing Mitochondrial and Cellular Bioenergetics in Human Pluripotent Stem Cells

  Alessandro Prigione and James Adjay

  Targeting Mitochondria 2010
  November 18-19, 2010
  Berlin, DE

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