Applications in Cancer

App Notes & Tech Briefs

• Screening for Mitochondrial Biogenesis and Toxicity

  A sensitive and robust cell-based screening assay.

  Mitochondrial damage compromises ATP production and consequentially cellular viability. Given the central role that mitochondria play in regulating cellular function, drugs that undermine mitochondrial function frequently elicit toxic effects...

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• Defining metabolic phenotypes in cancer cells

  Kinetic assay reveals the dynamic interplay of oxidative phosphorylation and glycolytic pathways

  Malignant transformation of cells is often characterized by aerobic glycolysis, the conversion of glucose into lactate, despite the presence of oxygen. This metabolic shift, known as the Warburg effect, can occur as a result of the activation or mutation of oncogenes or tumor suppressor genes, or as an adaptive response to hypoxia...

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• Measuring glycolysis and oxidative metabolism in cancer cells

  Real-time assay enables scientists to connect metabolic pathways with oncogenic phenotypes

  Measuring the metabolic pathways in cancer cells, and their co-dependent or compensatory interplay, is important for understanding transformation mechanisms, mechanisms of malignant growth, cancer cell drug resistance, and for discovering potential drugs that are relatively specific for cancer cells...

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• Metabolic Pathway Determination Using the XF24 Analyzer

  Measure Mitochondrial Respiration and Glycolysis Simultaneously

  The XF24 Analyzer non-invasively measures physiological changes in cellular bioenergetics and metabolic pathways in vitro using optical biosensors in a 24-well format. Shifts between mitochondrial respiration and glycolysis as a result of genetic, pharmacologic or environmental manipulation can be measured in a single assay. XF24 assays provide increased throughput in a drug discovery format.

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• Bioenergetic analysis of suspension cells: hematopoietic stem cells and lymphocytes

  A real time assay that quantifies the ATP and biosynthetic demands of immune cell proliferation, differentiation and effector function.

  Normal suspension cells, such as hematopoietic cells and lymphocytes are responsible for supplying oxygen to the body and protecting the host. Cellular metabolism is markedly dynamic in immune responses during proliferation and immune effector functions...

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Publications

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• Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

  Wu M, Neilson A, Swift A L, Moran R, Tamagnine J, Parslow D, Armistead S, Lemire K, Orrell J, Teich J, Chomicz S and Ferrick D A

  Am J Physiol Cell Physiol; 2007 Jan 1. 292 (1):C125-136.

• Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells

  Slomiany M G, Grass G D, Robertson A D, Yang X Y, Maria B L, Beeson C and Toole B P

  Cancer Res; 2009 Feb 15. 69 (4):1293-1301.

• LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

  Xie H, Valera V A, Merino M J, Amato A M, Signoretti S, Linehan W M, Sukhatme V P and Seth P

  Mol Cancer Ther; 2009 Mar 1. 8 (3):626-635.

• Methods in Cancer Metabolism: Real-Time Measurement of Mitochondrial Respiration and Glycolysis Rates of Cancer Cells in a Microplate

  Wu M

  Am. Assoc. Cancer Res. Education Book; 2009 Apr 1. :295-300.

• Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype

  de Groof A J, te Lindert M M, van Dommelen M M, Wu M, Willemse M, Smift A L, Winer M, Oerlemans F, Pluk H, Fransen J A and Wieringa B

  Mol Cancer; 2009 Jul 31. 8 (1):54.

• Polo-like kinases mediate cell survival in mitochondrial dysfunction

  Matsumoto T, Wang P Y, Ma W, Sung H J, Matoba S and Hwang P M

  Proc Natl Acad Sci U S A; 2009 Aug 25. 106 (34):14542-14546.

• Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104

  Cairns R A, Bennewith K L, Graves E E, Giaccia A J, Chang D T and Denko N C

  Clin Cancer Res; 2009 Dec 1. 15 (23):7170-7174.

• UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

  Yang Y, Valera V A, Padilla-Nash H M, Sourbier C, Vocke C D, Vira M A, Abu-Asab M S, Bratslavsky G, Tsokos M, Merino M J, Pinto P A, Srinivasan R, Ried T, Neckers L and Linehan W M

  Cancer Genet Cytogenet; 2010 Jan 1. 196 (1):45-55.

• Differential metabolic responses to pluronic in MDR and non-MDR cells: a novel pathway for chemosensitization of drug resistant cancers

  Alakhova D Y, Rapoport N Y, Batrakova E V, Timoshin A A, Li S, Nicholls D, Alakhov V Y and Kabanov A V

  J Control Release; 2010 Feb 25. 142 (1):89-100.

• Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose

  Blouin M J, Zhao Y, Zakikhani M, Algire C, Piura E and Pollak M

  Cancer Lett; 2010 Mar 28. 289 (2):246-253.

• Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

  Weinberg F, Hamanaka R, Wheaton W W, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu G M, Budinger G R and Chandel N S

  Proc Natl Acad Sci U S A; 2010 May 11. 107 (19):8788-8793.

• Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cells

  Delgado T, Carroll P A, Punjabi A S, Margineantu D, Hockenbery D M and Lagunoff M

  Proceedings of the National Academy of Sciences; 2010 Jun 8. 107 (23):10696-10701.

• Alterations in bioenergetics due to changes in mitochondrial DNA copy number

  Qian W and Van Houten B

  Methods; 2010 Aug 1. 51 (4):452-457.

• Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype

  Sanchez-Cenizo L, Formentini L, Aldea M, Ortega A D, Garcia-Huerta P, Sanchez-Arago M and Cuezva J M

  J Biol Chem; 2010 Aug 13. 285 (33):25308-25313.

• Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells

  Xiao D, Powolny A A, Moura M B, Kelley E E, Bommareddy A, Kim S H, Hahm E R, Normolle D, Van Houten B and Singh S V

  J Biol Chem; 2010 Aug 20. 285 (34):26558-26569.

• Preclinical Evaluation of Novel Triphenylphosphonium Salts with Broad-Spectrum Activity

  Millard M, Pathania D, Shabaik Y, Taheri L, Deng J and Neamati N

  PLoS One; 2010 Oct 4. 5 (10):e13131.

• Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents

  Mailloux R J, Adjeitey C N and Harper M E

  PLoS One; 2010 Oct 13. 5 (10):e13289.

• Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts

  Graves J A, Rothermund K, Wang T, Qian W, Van Houten B and Prochownik E V

  PLoS One; 2010 Oct 28. 5 (10):e13717.

• Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

  Pike L S, Smift A L, Croteau N J, Ferrick D A and Wu M

  Biochim Biophys Acta. 2010 Nov 12; [Epub ahead of print].

• Leptin Receptor Signaling Supports Cancer Cell Metabolism through Suppression of Mitochondrial Respiration in Vivo

  Park J, Kusminski C M, Chua S C and Scherer P E

  Am J Pathol; 2010 Dec 1. 177 (6):3133-3144.

• CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitation

  Chen V and Shtivelman E

  Cell Cycle; 2010 Dec 15. 9 (24):4941-4953.

• Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain

  Oliva C R, Nozell S E, Diers A, McClugage S G, 3rd, Sarkaria J N, Markert J M, Darley-Usmar V M, Bailey S M, Gillespie G Y, Landar A and Griguer C E

  J Biol Chem; 2010 Dec 17. 285 (51):39759-39767.

• Cytoprotective effect of gamma-tocopherol against tumor necrosis factor alpha induced cell dysfunction in L929 cells

  Olah G, Modis K, Gero D, Suzuki K, Dewitt D, Traber D L and Szabo C

  Int J Mol Med; 2011 Jan 1. 28 (5):711-720.

• On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate

  Seth P, Grant A, Tang J, Vinogradov E, Wang X, Lenkinski R and Sukhatme V P

  Neoplasia; 2011 Jan 1. 13 (1):60-71.

• The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil

  Sanchez-Arago M and Cuezva J M

  J Transl Med; 2011 Feb 10. 9 (19)

• Development of chromanes as novel inhibitors of the uncoupling proteins

  Rial E, Rodriguez-Sanchez L, Aller P, Guisado A, Mar Gonzalez-Barroso M, Gallardo-Vara E, Redondo-Horcajo M, Castellanos E, Fernandez de la Pradilla R and Viso A

  Chem Biol; 2011 Feb 25. 18 (2):264-274.

• Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

  Guo J Y, Chen H Y, Mathew R, Fan J, Strohecker A M, Karsli-Uzunbas G, Kamphorst J J, Chen G, Lemons J M, Karantza V, Coller H A, Dipaola R S, Gelinas C, Rabinowitz J D and White E

  Genes Dev; 2011 Mar 1. 25 (5):460-470.

• Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC

  Yamasaki T, Tran T A, Oz O K, Raj G V, Schwarz R E, Deberardinis R J, Zhang X and Brugarolas J

  Nat Rev Urol; 2011 Mar 1. 8 (3):165-171.

• Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells

  Benitez A C, Dai Z, Mann H H, Reeves R S, Margineantu D H, Gooley T A, Groh V and Spies T

  Proc Natl Acad Sci U S A; 2011 Mar 8. 108 (10):4081-4086.

• Pancreatic cancers require autophagy for tumor growth

  Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel J M, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai O S, Doglioni C, Bardeesy N and Kimmelman A C

  Genes Dev; 2011 Apr 1. 25 (7):717-729.

• Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

  Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole R N, Pandey A and Semenza G L

  Cell; 2011 May 27. 145 (5):732-744.

• Bax Supports the Mitochondrial Network, Promoting Bioenergetics in Non-Apoptotic Cells

  Boohaker R J, Zhang G, Carlson A L, Nemec K N and Khaled A R

  Am J Physiol Cell Physiol; 2011 Jun 1. 300 (6):466-478.

• Kinase Suppressor of Ras 1 (KSR1) Regulates PGC1{alpha} and Estrogen-Related Receptor {alpha} To Promote Oncogenic Ras-Dependent Anchorage-Independent Growth

  Fisher K W, Das B, Kortum R L, Chaika O V and Lewis R E

  Mol Cell Biol; 2011 Jun 1. 31 (12):2453-2461.

• AMPK regulates metabolism and survival in response to ionizing radiation

  Zannella V E, Cojocari D, Hilgendorf S, Vellanki R N, Chung S, Wouters B G and Koritzinsky M

  Radiother Oncol; 2011 Jun 1. 99 (3):293-299.

• High-mobility group box 1 is essential for mitochondrial quality control

  Tang D, Kang R, Livesey K M, Kroemer G, Billiar T R, Van Houten B, Zeh H J, 3rd and Lotze M T

  Cell Metab; 2011 Jun 8. 13 (6):701-711.

• Mitochondrial Phosphatase PTPMT1 Is Essential for Cardiolipin Biosynthesis

  Zhang J, Guan Z, Murphy A N, Wiley S E, Perkins G A, Worby C A, Engel J L, Heacock P, Nguyen O K, Wang J H, Raetz C R, Dowhan W and Dixon J E

  Cell Metab; 2011 Jun 8. 13 (6):690-700.

• Mitochondrial Dysfunction Impairs Tumor Suppressor p53 Expression/Function

  Compton S, Kim C, Griner N B, Potluri P, Scheffler I E, Sen S, Jerry D J, Schneider S and Yadava N

  J Biol Chem; 2011 Jun 10. 286 (23):20297-20312.

• Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3

  Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E

  J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.

• Dietary Fish Oil Promotes Colonic Apoptosis and Mitochondrial Proton Leak in Oxidatively Stressed Mice

  Fan Y Y, Ran Q, Toyokuni S, Okazaki Y, Callaway E S, Lupton J R and Chapkin R S

  Cancer Prev Res (Phila); 2011 Jul 1. 4 (18):1267-1274.

• The selective growth inhibition of oral cancer by iron core-gold shell nanoparticles through mitochondria-mediated autophagy

  Wu Y N, Yang L X, Shi X Y, Li I C, Biazik J M, Ratinac K R, Chen D H, Thordarson P, Shieh D B and Braet F

  Biomaterials; 2011 Jul 1. 32 (20):4565-4573.

• E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells

  Hatchi E, Rodier G, Lacroix M, Caramel J, Kirsh O, Jacquet C, Schrepfer E, Lagarrigue S, Linares L K, Lledo G, Tondeur S, Dubus P, Sardet C and Le Cam L

  J Exp Med; 2011 Jul 4. 208 (7):1403-1417.

• Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

  Parkhitko A, Myachina F, Morrison T A, Hindi K M, Auricchio N, Karbowniczek M, Wu J J, Finkel T, Kwiatkowski D J, Yu J J and Henske E P

  Proc Natl Acad Sci U S A; 2011 Jul 26. 108 (30):12455-12460.

• Akt-dependent glucose metabolism promotes mcl-1 synthesis to maintain cell survival and resistance to bcl-2 inhibition

  Coloff J L, Macintyre A N, Nichols A G, Liu T, Gallo C A, Plas D R and Rathmell J C

  Cancer Res; 2011 Aug 1. 71 (15):5204-5213.

• Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

  Chan D A, Sutphin P D, Nguyen P, Turcotte S, Lai E W, Banh A, Reynolds G E, Chi J T, Wu J, Solow-Cordero D E, Bonnet M, Flanagan J U, Bouley D M, Graves E E, Denny W A, Hay M P and Giaccia A J

  Sci Transl Med; 2011 Aug 3. 3 (94):94ra70.

• Withaferin a-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species

  Hahm E R, Moura M B, Kelley E E, Van Houten B, Shiva S and Singh S V

  PLoS One. 2011 Aug 10; [Epub ahead of print].

• Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

  Frezza C, Zheng L, Folger O, Rajagopalan K N, Mackenzie E D, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A, Kalna G, Tomlinson I P, Pollard P J, Watson D G, Deberardinis R J, Shlomi T, Ruppin E and Gottlieb E

  Nature; 2011 Aug 17. 477 (7363):225-8.

• Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism

  Cvrljevic A N, Akhavan D, Wu M, Martinello P, Furnari F B, Johnston A J, Guo D, Pike L, Cavenee W K, Scott A M, Mischel P S, Hoogenraad N J and Johns T G

  J Cell Sci; 2011 Sep 1. 124 (Pt 17):2938-2950.

• The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

  Tong W H, Sourbier C, Kovtunovych G, Jeong S Y, Vira M, Ghosh M, Romero V V, Sougrat R, Vaulont S, Viollet B, Kim Y S, Lee S, Trepel J, Srinivasan R, Bratslavsky G, Yang Y, Linehan W M and Rouault T A

  Cancer Cell; 2011 Sep 13. 20 (3):315-327.

• Metabolic state of glioma stem cells and nontumorigenic cells

  Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel P S and Pajonk F

  Proc Natl Acad Sci U S A; 2011 Sep 20. 108 (38):16062-16067.

• Involvement of mitophagy in oncogenic K-Ras-induced transformation: Overcoming a cellular energy deficit from glucose deficiency

  Kim J H, Kim H Y, Lee Y K, Yoon Y S, Xu W G, Yoon J K, Choi S E, Ko Y G, Kim M J, Lee S J, Wang H J and Yoon G

  Autophagy; 2011 Oct 1. 7 (10):1187-1198.

• NF-kappaB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

  Mauro C, Leow S C, Anso E, Rocha S, Thotakura A K, Tornatore L, Moretti M, De Smaele E, Beg A A, Tergaonkar V, Chandel N S and Franzoso G

  Nat Cell Biol; 2011 Oct 1. 13 (10):1272-1279.

• Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels

  Wang X and Moraes C T

  Mol Oncol; 2011 Oct 1. 5 (5):399-409.

• Chaperone-mediated autophagy is required for tumor growth

  Kon M, Kiffin R, Koga H, Chapochnick J, Macian F, Varticovski L and Cuervo A M

  Sci Transl Med; 2011 Nov 16. 3 (109):109ra117.

• Targeting chaperone-mediated autophagy in cancer

  Thorburn A and Debnath J

  Sci Transl Med; 2011 Nov 16. 3 (109):109ps145.

• Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model

  Ibrahim-Hashim A, Wojtkowiak J W, Ribeiro M d L C, Estrella V, Bailey K M, Cornnell H H, Gatenby R A and Gillies R J

  J Cancer Sci Ther S1; 2011 Nov 19.

• Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells

  Zhou Y, Tozzi F, Chen J, Fan F, Xia L, Wang J, Gao G, Zhang A, Xia X, Brasher H, Widger W, Ellis L M and Weihua Z

  Cancer Res; 2012 Jan 1. 72 (1):304-14.

• Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts

  Fabian C, Koetz L, Favaro E, Indraccolo S, Mueller-Klieser W and Sattler U G

  FEBS J. 2012 Jan 12; [Epub ahead of print].

• Identification and analysis of the active phytochemicals from the anti-cancer botanical extract bezielle

  Chen V, Staub R E, Baggett S, Chimmani R, Tagliaferri M, Cohen I and Shtivelman E

  PLoS One. 2012 Jan 17; [Epub ahead of print].

• Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells

  Chiu W H, Luo S J, Chen C L, Cheng J H, Hsieh C Y, Wang C Y, Huang W C, Su W C and Lin C F

  Biochem Pharmacol. 2012 Jan 20; [Epub ahead of print].

• Akt3 controls VEGF secretion and angiogenesis in ovarian cancer cells

  Liby T A, Spyropoulos P, Lindner H B, Eldridge J, Beeson C, Hsu T and Muise-Helmericks R C

  Int J Cancer; 2012 Feb 1. 130 (3):532-43.

• Mesenchymal Stromal Cells Protect Cancer Cells From ROS-induced Apoptosis and Enhance the Warburg Effect by Secreting STC1

  Ohkouchi S, Block G J, Katsha A M, Kanehira M, Ebina M, Kikuchi T, Saijo Y, Nukiwa T and Prockop D J

  Mol Ther; 2012 Feb 1. 20 (2):417-23.

• Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status

  Sandulache V C, Skinner H D, Ow T J, Zhang A, Xia X, Luchak J M, Wong L J, Pickering C R, Zhou G and Myers J N

  Cancer; 2012 Feb 1. 118 (3):711-21.

• Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

  Yang J, Staples O, Thomas L W, Briston T, Robson M, Poon E, Simoes M L, El-Emir E, Buffa F M, Ahmed A, Annear N P, Shukla D, Pedley B, Maxwell P H, Harris A L and Ashcroft M

  J Clin Invest; 2012 Feb 1. 122 (2):600-11.

• Dysregulation of Ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma

  Ren L, Hong S H, Chen Q R, Briggs J, Cassavaugh J, Srinivasan S, Lizardo M M, Mendoza A, Xia A Y, Avadhani N, Khan J and Khanna C

  Cancer Res. 2012 Feb 2; [Epub ahead of print].

• Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1

  Wernstedt Asterholm I, Mundy D I, Weng J, Anderson R G and Scherer P E

  Cell Metab; 2012 Feb 8. 15 (2):171-185.

• Bezielle Selectively Targets Mitochondria of Cancer Cells to Inhibit Glycolysis and OXPHOS

  Chen V, Staub R E, Fong S, Tagliaferri M, Cohen I and Shtivelman E

  PLoS One. 2012 Feb 10; [Epub ahead of print].

Technical Posters

Sort by: Title | Author | Date

• Synergistic enhancement of 2-deoxy-D-glucose-mediated breast cancer cell death by mitochondria-targeted drugs

  Gang Cheng, Donna McAllister, Jacek Zielonka, Brian P. Dranka, Joy Joseph, Balaraman. Kalyanaraman

  Society for Free Radical Biology and Medicine (SFRBM) 2011
  November 16-20, 2011
  Atlanta, GA

• Selective killing of breast cancer cells by mitochondria-targeted alpha-tocopherol

  Jacek Zielonka, Gang Cheng, Jin-Hwan Kim, Joy Joseph, B. Kalyanaraman

  Society for Free Radical Biology and Medicine (SFRBM) 2011
  November 16-20, 2011
  Atlanta, GA

• Breast cancer, statins and 3Dcell culture

  Peter Mullen

  AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics 2011
  November 12-16, 2011
  San Francisco, CA

• The combination of statins and dipyridamole is effective preclinically in multiple myeloma, acute myelogenous leukemia and breast cancer

  A. Pandyra, P. Sobol, P.J. Mullen, A.D. Schimmer, L.Z. Penn

  AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics 2011
  November 12-16, 2011
  San Francisco, CA

• Bioenergetics of tumors: role of sequential oncogenes activation and microenvironment in the determination of cancer cells metabolic profile.

  Caroline Jose, Etienne Harbert Chatelain, Giovanni Benard, Su Melser and Rodrigue Rossignol

  Mitochondria, Apoptosis and Cancer (MAC '11)
  October 27-29, 2011
  Singapore

• Dysregulation of c-terminal ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma

  Ling Ren, Sung-Hyeok Hong, Qing-Rong Chen, Joseph Briggs, Jessica Cassavaugh, Satish Srinivasan, Narayan Avadhani, Javed Khan, Chand Khanna

  AACR Special Conference: Metabolism and Cancer 2011
  October 16-19, 2011
  Baltimore, MD

• Fenofibrate-mediated inhibition of mitochondrial respiration activates FOXO3a-BIM apoptotic pathway in human Glioblastoma cells in vitro

  Anna Wilk, Katarzyna Urbanska, David Impastato, Krzysztof Reiss

  AACR Special Conference: Metabolism and Cancer 2011
  October 16-19, 2011
  Baltimore, MD

• AMPK regulates metabolism and survival in response to ionizing radiation

  Vanessa E Zannella, Dan Cojocari, Susan Hilgendorf, Ravi N Vellanki, Stephen Chung, Bradly G Wouters, Marianne Koritzinsky

  AACR Special Conference: Metabolism and Cancer 2011
  October 16-19, 2011
  Baltimore, MD

• Novel molecular features associated with sensitivity to the anticancer effects of statins in breast tumour cells

  Carolyn A. Goard, Michelle A. Chan-Seng-Yue, Peter J. Mullen, James W. Clendening, Dorota H. S. Sendorek, Paul C. Boutros, Linda Z. Penn

  AACR Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications
  October 12-15, 2011
  San Francisco, CA

• Manipulation of lactate metabolism and radiation resistance in two human ovarian cancer cell lines

  Christian G. Fabian, Andrea Siebers, Ulrike G. A. Sattler, Wolfgang Mueller-Klieser

  14th International Congress of Radiation Research
  August 28-1, 2011
  Warsaw, Poland

• 14-3-3sigma as a new important regulator of cancer glycolysis

  Liem Phan, Ismael Samudio, Ping-Chieh Chou, Guermarie Velazquez-Torres, Hyun-Ho Choi, Edward Wang, Christopher Gully, Enrique Fuentes-Mattei

  Cold Spring Harbor Laboratory 76th Symposium of Metabolism and Disease
  June 2-3, 2011
  Cold Spring Harbor, NY

• Preclinical studies of novel phosphonium salts with broad-spectrum activity

  Melissa Millard, Divya Pathania, Yumna Shabaik, Laleh Taheri, Jinxia Deng, Nouri Neamati

  AACR Annual Meeting 2011
  April 2-6, 2011
  Orlando, FL

• Modulation of metabolic substrate uptake by the nitrosating agent, S-nitrosocysteine: Impact on bioenergetics of breast cancer cells

  Broniowska, Katarzyna

  Gordon Research Conference on Nitric Oxide
  February 13-18, 2011
  Ventura, CA

• Uptake, Subcellular Localization, Bioenergetic Effects and Antiproliferative Properties of Triphenylphosphonium‐Linked Nitroxides in Breast Cancer Cells

  Gang Cheng, Jacek Zielonka, Brian P. Dranka, Joy Joseph, Balaraman. Kalyanaraman

  Society for Free Radical Biology's 17th Annual Meeting
  November 17-20, 2010
  Orlando, FL

• Energy Metabolism and Radiosensitivity of Two HNSCC Tumor Cell Lines

  Christian G. Fabian, Wolfgang Mueller-Klieser, Ulrike G. A. Sattler

  56th Annual Meeting of the Radiation Research Society
  September 27, 2010
  Wailea, HI

• Energy Metabolism in Genetically Defined Subtypes of Diffuse Large B Cell Lymphoma

  Pilar Caro, Amar Kishan, Daniel Tondera, Alfredo Gimenez-Cassina, Margaret Shipp, Nika N. Dania

  Cancer and Metabolism: Pathways to the Future Conference
  September 19-21, 2010
  Edinburgh, Scotland

• Bioenergetic Differences in Breast Cancer Cell Lines

  Dilshan S. Harischandra and David Hockenbery

  AACR Metabolism & Cancer Conference
  September 13-16, 2009
  La Jolla, CA

• Cells Addicted to BCL-XL Accumulate Succinate via Pyruvate Carboxylase Metabolism and Glutaminolysis

  Daciana Margineantu and David Hockenbery

  AACR Metabolism & Cancer Conference
  September 13-16, 2009
  La Jolla, CA

• KSR1, a RAS-RAF-MEK Signal Cascade Protein Necessary for H-Ras-Induced Oncogenic Transformation, is Also Required for Uptake/Consumption of Glucose, Glutamine and Fatty Acid in Mouse Embryonic Fibroblasts

  Amy L. Swift, Denise Chen, Kurt Fisher, Mike Winer1, David A. Ferrick1 Robert E. Lewis and Min Wu

  American Association for Cancer Research 100th Annual Meeting
  April 9, 2009
  Denver, CO

• Real-Time Metabolic Analysis of Glioblastoma Cells Treated with 2-Deoxyglucose Reveals a Metabolic Switch to Aerobic Energy Metabolism Mediated By HIF-1a

  Min Wu, Amy Swift, Rebecca Moran and David Ferric

  American Association for Cancer Research 2006 Annual Meeting
  April 1, 2006
  Washington, DC

• A Novel Assay for Profiling Metabolic Changes Mediated By HIF-1a in Cancer Cells

  Min Wu, Amy Swift, Diane Parslow, Suzanne Armitstead, Kristie Lemire, David Ferrick

  Tumor Metabolism Summit
  September 19, 2005
  Genoa, Italy

• A Non-Destructive, Time-Resolved, Multi-Analyte Technology for Sensing Metabolic Changes in Cancer Cells

  Min Wu, Andy Neilson, Jay Teich, James Tamagnine, Diane Parslow, Kristie Lemire, Suzanne Armitstead and Steve Chomicz

  American Association for Cancer Research 2005
  April 19, 2005
  anaheim, CA

Webinars

Sort by: Title | Speaker | Date
• 

  XF Glycolysis Stress Test Assesses Glycolysis and Glycolytic Capacity in Cells

  Min Wu, PhD, Seahorse Bioscience
  August 30, 2011

• 

  Multidimensional control of mitochondrial energy production: learning from physiology and pathology

  Rodrigue Rossignol, PhD, Université de Bordeaux
  April 27, 2011

• 

  Metabolic Reprogramming Therapy in the Treatment of Cancer

  Nicholas Denko, MD, PhD, Stanford University, School of Medicine
  October 27, 2010

• 

  Mitochondria Regulate Cancer

  Navdeep S. Chandel, PhD, Northwestern Medical School
  September 22, 2010

• 

  Analysis of Glutaminolysis and Fumarate Respiration in Bcl-xL-expressing Cells

  David M. Hockenbery, MD, Internal Medicine at the University of Washington
  April 14, 2010

• 

  Molecular Scaffolds KSR1/2: Implications for Obesity and Cancer

  Robert Lewis, PhD, University of Nebraska Cancer Center
  March 24, 2010

• 

  Oxidative Stress, Mitochondrial DNA Damage and Human Disease: How mitochondria repair their genome and how to measure mtDNA repair using quantitative PCR

  Ben Van Houten, PhD, University of Pittsburgh Cancer Institute
  May 21, 2009

• 

  Tutorial 2: Measuring Bioenergetics in Primary Cell Types

  David Ferrick, PhD, CSO, Seahorse Bioscience
  August 27, 2008

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