Applications in Aging

App Notes & Tech Briefs

• Screening for Mitochondrial Biogenesis and Toxicity

  A sensitive and robust cell-based screening assay.

  Mitochondrial damage compromises ATP production and consequentially cellular viability. Given the central role that mitochondria play in regulating cellular function, drugs that undermine mitochondrial function frequently elicit toxic effects...

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Publications

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• Ethanol withdrawal hastens the aging of cytochrome c oxidase

  Jung M E, Ju X, Metzger D B and Simpkins J W

  Neurobiol Aging; 2012 Mar 1. 33 (3):618.e21-32.

• ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome

  Grunewald A, Arns B, Seibler P, Rakovic A, Munchau A, Ramirez A, Sue C M and Klein C

  Neurobiol Aging. 2012 Jan 30; [Epub ahead of print].

• The role of nuclear lamin B1 in cell proliferation and senescence

  Shimi T, Butin-Israeli V, Adam S A, Hamanaka R B, Goldman A E, Lucas C A, Shumaker D K, Kosak S T, Chandel N S and Goldman R D

  Genes Dev; 2011 Dec 15. 25 (24):2579-2593.

• Identification and characterization of a functional mitochondrial angiotensin system

  Abadir P M, Foster D B, Crow M, Cooke C A, Rucker J J, Jain A, Smith B J, Burks T N, Cohn R D, Fedarko N S, Carey R M, O'Rourke B and Walston J D

  Proc Natl Acad Sci U S A; 2011 Sep 6. 108 (36):14849-14854.

• Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3

  Mailloux R J, Seifert E L, Bouillaud F, Aguer C, Collins S and Harper M E

  J Biol Chem; 2011 Jun 17. 286 (24):21865-21875.

• Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes

  Choi S W, Gerencser A A, Lee D W, Rajagopalan S, Nicholls D G, Andersen J K and Brand M D

  J Neurosci; 2011 Mar 23. 31 (12):4524-4534.

• Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts

  Zhang Y, Zhang H M, Shi Y, Lustgarten M, Li Y, Qi W, Zhang B X and Van Remmen H

  Free Radic Biol Med; 2010 Nov 1. 49 (8):1255-1262.

• Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL

  Civitarese A E, MacLean P S, Carling S, Kerr-Bayles L, McMillan R P, Pierce A, Becker T C, Moro C, Finlayson J, Lefort N, Newgard C B, Mandarino L, Cefalu W, Walder K, Collier G R, Hulver M W, Smith S R and Ravussin E

  Cell Metab; 2010 May 5. 11 (5):412-426.

• Bmi1 regulates mitochondrial function and the DNA damage response pathway

  Liu J, Cao L, Chen J, Song S, Lee I H, Quijano C, Liu H, Keyvanfar K, Chen H, Cao L Y, Ahn B H, Kumar N G, Rovira, II, Xu X L, van Lohuizen M, Motoyama N, Deng C X and Finkel T

  Nature; 2009 May 21. 459 (7245):387-392.

• Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

  Wu J J, Quijano C, Chen E, Liu H, Cao L, Fergusson M M, Rovira, II, Gutkind S, Daniels M P, Komatsu M and Finkel T

  Aging (Albany NY); 2009 Apr 1. 1 (4):425-437.

Technical Posters

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• The Homeobox Protein Prox1 is a Negative Modulator of ERRα/PGC-1α Bioenergetic Functions

  Alexis Charest-Marcotte, Catherine R. Dufour, Brian J. Wilson, Annie M. Tremblay, Lillian J. Eichner, Daniel H. Arlow, Vamsi K. Mootha and Vincent Gigu

  Nuclear Receptors: Development, Physiology and Disease
  March 21-26, 2010
  Keystone, CO

• Testing Modulators of Uncoupling Protein (UCP) Function in Intact HEK293 Cells Using Plate-Based Respirometry and Membrane Potential Sensitive Fluorescent Probes

  Martin Jastroch, Akos A. Gerencser, and Martin D. Brand

  Molecular & Cellular Bioenergetics Gordon Research Conference
  June 10, 2009
  Keystone, CO

Webinars

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• 

  Biochemical analysis in C. elegans as a model for metabolic disease and aging

  Laurent Mouchiroud, PhD , École Polytechnique Fédérale de Lausanne
  Riekelt H. Houtkooper, PhD, École Polytechnique Fédérale de Lausanne
  November 30, 2011

• 

  Spare Respiratory Capacity and the Bioenergetics of the Nerve Terminal

  David Nicholls, PhD, FRSE, Buck Institute for Age Research & Lund University
  December 3, 2009

• 

  The Bioenergetics of Obesity: New Approaches to Characterize Genes Affecting Energy Balance in Mouse Models

  Karen Reue, PhD, David Geffen School of Medicine at UCLA
  April 30, 2009

• 

  The Response of the Mitochondrion to Oxidative Stress in Cardiovascular Cells

  Victor Darley-Usmar, PhD, University of Alabama at Birmingham
  November 11, 2008

• 

  Thyroid Hormone Deiodination is a Key Switch for Energy Expenditure

  Antonio C. Bianco, MD, PhD, Brigham and Women’s Hospital & Harvard Medical School
  March 25, 2008

• 

  Bioenergetic Consequences of Mitochondrial Fusion and Fission

  Orian Shirihai, MD, PhD , Tufts University School of Medicine
  January 30, 2008

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